Mjos O D, Miller N E, Riemersma R A, Oliver M F
Circulation. 1976 Mar;53(3):494-500. doi: 10.1161/01.cir.53.3.494.
The effect of p-chlorophenoxyisobutyrate (CPIB) on ST-segment elevation in epicardial electrocardiographic recordings was studied during coronary artery occlusion in dogs. Occlusion alone raised the sum of ST-segment elevations (sigmaST) to 26 +/- 6 mV (mean +/- SEM). Intravenous (i.v.) administration of CPIB 30 min before re-occlusion reduced sigmaST to 14 +/- 3 mV (P less than 0.03). A continuous i.v. infusion of isoproterenol increased sigmaST to 74 +/- 11 mV. Pretreatment with CPIB reduced sigmaST during isoproterenol infusion to 40 +/- 7 mV (P less than 0.005). CPIB had no effect on mean aortic blood pressure, heart rate, or regional myocardial blood flow, as measured by radioactive microspheres. Arterial free fatty acid (FFA) concentrations were reduced by CPIB from 466 +/- 41 to 221 +/- 44 muEq/L (P less than 0.001) in the basal state, and from 1966 +/- 183 to 1429 +/- 209 muEq/L (P less than 0.001) during isoproterenol infusion. The reduction in arterial FFA concentration was associated with a proportionate decrease in the myocardial extraction of FFA. Similar changes were observed when CPIB was administered during an occlusion which had been established 10 min earlier. These observations support other evidence that the severity of acute myocardial ischemic injury in dogs is positively correlated with the myocardial extraction of FFA, and that the severity of the ischemic injury can be reduced by effective antilipolytic therapy.
在犬冠状动脉闭塞期间，研究了对氯苯氧异丁酸（CPIB）对心外膜心电图记录中ST段抬高的影响。单独闭塞使ST段抬高总和（sigmaST）升至26±6mV（均值±标准误）。再闭塞前30分钟静脉注射（i.v.）CPIB可使sigmaST降至14±3mV（P<0.03）。持续静脉输注异丙肾上腺素可使sigmaST升至74±11mV。CPIB预处理可使异丙肾上腺素输注期间的sigmaST降至40±7mV（P<0.005）。通过放射性微球测量，CPIB对平均主动脉血压、心率或局部心肌血流无影响。在基础状态下，CPIB可使动脉游离脂肪酸（FFA）浓度从466±41降至221±44μEq/L（P<0.001），在异丙肾上腺素输注期间从1966±183降至1429±209μEq/L（P<0.001）。动脉FFA浓度的降低与心肌FFA摄取的相应减少相关。在提前10分钟建立的闭塞期间给予CPIB时，观察到类似变化。这些观察结果支持其他证据，即犬急性心肌缺血损伤的严重程度与心肌FFA摄取呈正相关，并且有效的抗脂解治疗可降低缺血损伤的严重程度。
