Hoffman R
Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, U.K.
Biochem J. 1993 Jan 15;289 ( Pt 2)(Pt 2):331-4. doi: 10.1042/bj2890331.
Carrageenans, a family of polysulphated carbohydrates, inhibited binding of basic fibroblast growth factor (bFGF), transforming growth factor beta 1 (TGF beta 1) and platelet-derived growth factor (PDGF). iota-Carrageenan was the most potent bFGF antagonist (IC50 = 0.4 +/- 0.1 microgram/ml), kappa-carrageenan was the most potent PDGF antagonist (IC50 = 1.7 +/- 1.3 micrograms/ml) and lambda-carrageenan was the most potent TGF beta 1 antagonist (IC50 = 19 +/- 2 micrograms/ml). None of the carrageenans, at concentrations up to 200 micrograms/ml, inhibited binding of insulin-like growth factor 1 or transforming growth factor alpha. Carrageenans are selective growth-factor antagonists and have potential for the treatment of disorders associated with the over-production of certain growth factors.
角叉菜胶是一类多硫酸化碳水化合物，它能抑制碱性成纤维细胞生长因子（bFGF）、转化生长因子β1（TGFβ1）和血小板衍生生长因子（PDGF）的结合。ι-角叉菜胶是最有效的bFGF拮抗剂（IC50 = 0.4 ± 0.1微克/毫升），κ-角叉菜胶是最有效的PDGF拮抗剂（IC50 = 1.7 ± 1.3微克/毫升），而λ-角叉菜胶是最有效的TGFβ1拮抗剂（IC50 = 19 ± 2微克/毫升）。在浓度高达200微克/毫升时，没有一种角叉菜胶能抑制胰岛素样生长因子1或转化生长因子α的结合。角叉菜胶是选择性生长因子拮抗剂，对于治疗与某些生长因子过度产生相关的疾病具有潜力。
