角叉菜胶会抑制生长因子结合。
Carrageenans inhibit growth-factor binding.
作者信息
Hoffman R
机构信息
Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, U.K.
出版信息
Biochem J. 1993 Jan 15;289 ( Pt 2)(Pt 2):331-4. doi: 10.1042/bj2890331.
Abstract
Carrageenans, a family of polysulphated carbohydrates, inhibited binding of basic fibroblast growth factor (bFGF), transforming growth factor beta 1 (TGF beta 1) and platelet-derived growth factor (PDGF). iota-Carrageenan was the most potent bFGF antagonist (IC50 = 0.4 +/- 0.1 microgram/ml), kappa-carrageenan was the most potent PDGF antagonist (IC50 = 1.7 +/- 1.3 micrograms/ml) and lambda-carrageenan was the most potent TGF beta 1 antagonist (IC50 = 19 +/- 2 micrograms/ml). None of the carrageenans, at concentrations up to 200 micrograms/ml, inhibited binding of insulin-like growth factor 1 or transforming growth factor alpha. Carrageenans are selective growth-factor antagonists and have potential for the treatment of disorders associated with the over-production of certain growth factors.
摘要
角叉菜胶是一类多硫酸化碳水化合物，它能抑制碱性成纤维细胞生长因子（bFGF）、转化生长因子β1（TGFβ1）和血小板衍生生长因子（PDGF）的结合。ι-角叉菜胶是最有效的bFGF拮抗剂（IC50 = 0.4 ± 0.1微克/毫升），κ-角叉菜胶是最有效的PDGF拮抗剂（IC50 = 1.7 ± 1.3微克/毫升），而λ-角叉菜胶是最有效的TGFβ1拮抗剂（IC50 = 19 ± 2微克/毫升）。在浓度高达200微克/毫升时，没有一种角叉菜胶能抑制胰岛素样生长因子1或转化生长因子α的结合。角叉菜胶是选择性生长因子拮抗剂，对于治疗与某些生长因子过度产生相关的疾病具有潜力。
相似文献
1
Carrageenans inhibit growth-factor binding.角叉菜胶会抑制生长因子结合。
Biochem J. 1993 Jan 15;289 ( Pt 2)(Pt 2):331-4. doi: 10.1042/bj2890331.
2
Inhibition of binding of basic fibroblast growth factor to low and high affinity receptors by carrageenans.角叉菜胶对碱性成纤维细胞生长因子与低亲和力和高亲和力受体结合的抑制作用。
Biochem Pharmacol. 1993 Jun 9;45(11):2348-51. doi: 10.1016/0006-2952(93)90210-n.
3
Selective inhibition of cell proliferation and DNA synthesis by the polysulphated carbohydrate l-carrageenan.
Cancer Chemother Pharmacol. 1995;36(4):325-34. doi: 10.1007/BF00689050.
4
[Carrageenan oligosaccharides inhibit growth-factor binding and heparanase activity].卡拉胶寡糖抑制生长因子结合和乙酰肝素酶活性
Yao Xue Xue Bao. 2011 Mar;46(3):280-4.
5
Cellular distribution of platelet-derived growth factor, transforming growth factor-beta, basic fibroblast growth factor, and their receptors in normal bone marrow.血小板衍生生长因子、转化生长因子-β、碱性成纤维细胞生长因子及其受体在正常骨髓中的细胞分布
Acta Haematol. 2000;104(4):151-7. doi: 10.1159/000046507.
6
Regulation of cell proliferation and urokinase plasminogen activation of human breast epithelial cells by carrageenans.
Int J Oncol. 1998 Jun;12(6):1397-401. doi: 10.3892/ijo.12.6.1397.
7
CDGF (chicken embryo fibroblast-derived growth factor) is mitogenically related to TGF-beta and modulates PDGF, bFGF, and IGF-I action on sparse NIH/3T3 cells.鸡胚成纤维细胞衍生生长因子（CDGF）与转化生长因子-β（TGF-β）在促有丝分裂方面相关，并调节血小板衍生生长因子（PDGF）、碱性成纤维细胞生长因子（bFGF）和胰岛素样生长因子-I（IGF-I）对稀疏的NIH/3T3细胞的作用。
Exp Cell Res. 1993 Feb;204(2):329-35. doi: 10.1006/excr.1993.1040.
8
Immunohistochemical expression of growth factors in subacute thyroiditis and their effects on thyroid folliculogenesis and angiogenesis in collagen gel matrix culture.生长因子在亚急性甲状腺炎中的免疫组化表达及其在胶原凝胶基质培养中对甲状腺滤泡生成和血管生成的影响
J Pathol. 1999 Aug;188(4):415-22. doi: 10.1002/(SICI)1096-9896(199908)188:4<415::AID-PATH380>3.0.CO;2-H.
9
Expression of PDGF, IGF-II, bFGF and TGF-beta 1 in pulmonary adenocarcinoma.
Pathol Res Pract. 1996 Nov;192(11):1113-20. doi: 10.1016/s0344-0338(96)80028-8.
10
Interactions of cultured endothelial cells with TGF-beta, bFGF, PDGF and IGF-I.培养的内皮细胞与转化生长因子-β、碱性成纤维细胞生长因子、血小板衍生生长因子和胰岛素样生长因子-I的相互作用。
Life Sci. 1991;48(8):811-21. doi: 10.1016/0024-3205(91)90097-u.
引用本文的文献
1
Biocompatible Macroion/Growth Factor Assemblies for Medical Applications.用于医疗应用的生物相容大分子/生长因子组装体。
Biomolecules. 2023 Mar 28;13(4):609. doi: 10.3390/biom13040609.
2
Growth factor and macromolecular crowding supplementation in human tenocyte culture.人肌腱细胞培养中的生长因子和大分子拥挤补充
Biomater Biosyst. 2021 Jan 30;1:100009. doi: 10.1016/j.bbiosy.2021.100009. eCollection 2021 Mar.
3
Bioactive Carbohydrate Polymers-Between Myth and Reality.生物活性碳水化合物聚合物——介于神话与现实之间。
Molecules. 2021 Nov 23;26(23):7068. doi: 10.3390/molecules26237068.
4
λ-Carrageenan Oligosaccharides of Distinct Anti-Heparanase and Anticoagulant Activities Inhibit MDA-MB-231 Breast Cancer Cell Migration.具有不同抗乙酰肝素酶和抗凝血活性的 λ-卡拉胶低聚糖可抑制 MDA-MB-231 乳腺癌细胞迁移。
Mar Drugs. 2019 Feb 27;17(3):140. doi: 10.3390/md17030140.
5
Marine algae sulfated polysaccharides for tissue engineering and drug delivery approaches.用于组织工程和药物递送方法的海洋藻类硫酸化多糖。
Biomatter. 2012 Oct-Dec;2(4):278-89. doi: 10.4161/biom.22947.
6
Carrageenan reduces bone morphogenetic protein-4 (BMP4) and activates the Wnt/beta-catenin pathway in normal human colonocytes.角叉菜胶可降低正常人结肠细胞中的骨形态发生蛋白-4（BMP4）水平，并激活Wnt/β-连环蛋白信号通路。
Dig Dis Sci. 2007 Oct;52(10):2766-74. doi: 10.1007/s10620-006-9531-4. Epub 2007 Apr 12.
7
Review of harmful gastrointestinal effects of carrageenan in animal experiments.卡拉胶在动物实验中对胃肠道有害影响的综述。
Environ Health Perspect. 2001 Oct;109(10):983-94. doi: 10.1289/ehp.01109983.
8
Effect of heparin on dextran sulfate sodium-induced colitis.
Dig Dis Sci. 1998 Aug;43(8):1800-5. doi: 10.1023/a:1018800207063.
9
Selective inhibition of cell proliferation and DNA synthesis by the polysulphated carbohydrate l-carrageenan.
Cancer Chemother Pharmacol. 1995;36(4):325-34. doi: 10.1007/BF00689050.
本文引用的文献
1
2
Suramin binds to platelet-derived growth factor and inhibits its biological activity.苏拉明与血小板衍生生长因子结合并抑制其生物活性。
J Cell Biochem. 1985;29(3):265-73. doi: 10.1002/jcb.240290310.
3
Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet-derived growth factor-like protein which is secreted.主动脉内皮细胞合成与细胞相关的碱性成纤维细胞生长因子以及分泌的血小板衍生生长因子样蛋白。
J Cell Physiol. 1987 Jun;131(3):402-8. doi: 10.1002/jcp.1041310312.
4
Suramin inhibition of growth factor receptor binding and mitogenicity in AKR-2B cells.苏拉明对AKR - 2B细胞中生长因子受体结合及促有丝分裂活性的抑制作用
J Cell Physiol. 1987 Jul;132(1):143-8. doi: 10.1002/jcp.1041320120.
5
High and low affinity binding sites for basic fibroblast growth factor on cultured cells: absence of a role for low affinity binding in the stimulation of plasminogen activator production by bovine capillary endothelial cells.培养细胞上碱性成纤维细胞生长因子的高亲和力和低亲和力结合位点：低亲和力结合在牛毛细血管内皮细胞纤溶酶原激活物产生刺激中无作用。
J Cell Physiol. 1987 Apr;131(1):123-30. doi: 10.1002/jcp.1041310118.
6
Methods for studying the platelet-derived growth factor receptor.研究血小板衍生生长因子受体的方法。
Methods Enzymol. 1985;109:69-100. doi: 10.1016/0076-6879(85)09078-4.
7
An assay for type-beta transforming growth factor receptor.
Methods Enzymol. 1987;146:167-73. doi: 10.1016/s0076-6879(87)46019-9.
8
Analysis of the inhibition of tumour metastasis by sulphated polysaccharides.
Int J Cancer. 1987 Jan 15;39(1):82-8. doi: 10.1002/ijc.2910390115.
9
Immunoregulatory processes induced by carrageenan in BALB/C mice.角叉菜胶在BALB/C小鼠中诱导的免疫调节过程。
Immunol Invest. 1990 Apr;19(2):163-83. doi: 10.3109/08820139009042035.
10
Suramin blockade of insulinlike growth factor I-stimulated proliferation of human osteosarcoma cells.苏拉明对胰岛素样生长因子I刺激的人骨肉瘤细胞增殖的阻断作用。
J Natl Cancer Inst. 1990 Aug 15;82(16):1349-52. doi: 10.1093/jnci/82.16.1349.
Zotero 插件