不完全弗氏佐剂对DA大鼠佐剂性关节炎的抑制作用
Suppression of adjuvant-induced arthritis in DA rats by incomplete Freund's adjuvant.
作者信息
Cannon G W, Griffiths M M, Woods M L
机构信息
Salt Lake City Veterans Affairs Medical Center, UT.
出版信息
Arthritis Rheum. 1993 Jan;36(1):126-31. doi: 10.1002/art.1780360120.
OBJECTIVE
To define the effects of incomplete Freund's adjuvant (ICFA) on subsequent arthritis induced by complete Freund's adjuvant (CFA) and type II collagen (CII) in DA and Lewis rats.
METHODS
ICFA was injected into DA and Lewis rats before CFA or CII injection.
RESULTS
DA rats previously injected with ICFA had significantly less severe arthritis induced by CFA compared with those not receiving ICFA pretreatment (P < 0.01). ICFA had no significant impact on CFA-induced arthritis in Lewis rats or on CII-induced arthritis in DA rats.
CONCLUSION
The injection of ICFA alone specifically suppresses subsequent CFA-induced arthritis in DA rats, but not in Lewis rats.
目的
确定不完全弗氏佐剂（ICFA）对随后由完全弗氏佐剂（CFA）和II型胶原（CII）诱导的DA和Lewis大鼠关节炎的影响。
方法
在注射CFA或CII之前，将ICFA注射到DA和Lewis大鼠体内。
结果
与未接受ICFA预处理的大鼠相比，先前注射ICFA的DA大鼠由CFA诱导的关节炎严重程度明显减轻（P < 0.01）。ICFA对Lewis大鼠中CFA诱导的关节炎或DA大鼠中CII诱导的关节炎没有显著影响。
结论
单独注射ICFA可特异性抑制随后DA大鼠中CFA诱导的关节炎，但对Lewis大鼠无效。
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