Sharkey F E
Am J Clin Pathol. 1977 Mar;67(3):272-8. doi: 10.1093/ajcp/67.3.272.
In an evaluation of the WHO classification of salivary gland tumors, 339 major and 27 minor salivary gland tumors were examined, these being all available cases seen at The New York Hospital during the years 1948-1968. The clinical records were examined and follow-up data (average 8.7 years) were obtained in 88% of cases. The relative incidences of sites and tumor types were similar to those in previously reported series. The WHO classification was found to be applicable to this group of tumors with the following exceptions: (1) cases of chronic sialedenitis, and lymphomas presenting primarily as salivary gland masses (4.1% of all cases in this series), do not appear in this classification but frequently present problems to the pathologist and ought to be included in any subsequent revision; (2) the histologic concept of "differentiation" was not helpful in predicting the outcome of cases of mucoepidermoid tumor and acinic-cell tumor; (3) some confusion, possibly justified, still exists between poorly differentiated acinic-cell tumors and adenocarcinomas; (4) a high frequency of atypical histologic types was encountered among the minor salivary gland tumors, suggesting that this group might benefit from separate treatment. Adequate surgical excision of the primary lesion was again found to play a decisive role in the eventual clinical result. In conclusion, the WHO classification of salivary gland tumors proved to be a practical guide for the categorization of the vast majority of this group of lesions.
在对世界卫生组织（WHO）唾液腺肿瘤分类的一项评估中，检查了339例大唾液腺肿瘤和27例小唾液腺肿瘤，这些是1948年至1968年间纽约医院所有可获得的病例。检查了临床记录，并在88%的病例中获得了随访数据（平均8.7年）。部位和肿瘤类型的相对发病率与先前报道的系列相似。发现WHO分类适用于这组肿瘤，但有以下例外情况：（1）慢性涎腺炎病例以及主要表现为唾液腺肿块的淋巴瘤（本系列所有病例的4.1%）未出现在该分类中，但经常给病理学家带来问题，应纳入任何后续修订版中；（2）“分化”的组织学概念对预测黏液表皮样癌和腺泡细胞癌病例的预后并无帮助；（3）低分化腺泡细胞癌和腺癌之间仍存在一些可能合理的混淆；（4）在小唾液腺肿瘤中遇到非典型组织学类型的频率较高，表明该组肿瘤可能需要单独治疗。再次发现对原发病变进行充分的手术切除对最终的临床结果起决定性作用。总之，WHO唾液腺肿瘤分类被证明是对这组病变中绝大多数进行分类的实用指南。
