Cole R B, Lawson E, Newfeld E A, Paul M H, Bharati S, Lev M
Am J Dis Child. 1977 Mar;131(3):281-5. doi: 10.1001/archpedi.1977.02120160035004.
Both atrial septal defect and patent ductus arteriosus are common isolated lesions, each accounting for approximately 10% of the total incidence of congenital heart diseases. Yet, the combination of these defects, without other significant cardiac lesions, is infrequent. We review the clinical and pathologic data on 16 patients with this combination of defects, including cardiac catheterization data on eight patients. In patients with this combination, we found an unusually high incidence of severe pulmonary hypertension, multiple noncardiac anomalies, mental retardation, and early mortality.
房间隔缺损和动脉导管未闭都是常见的孤立性病变，各占先天性心脏病总发病率的约10%。然而，这些缺损合并存在且无其他重要心脏病变的情况并不常见。我们回顾了16例患有这种联合缺损患者的临床和病理资料，包括8例患者的心导管检查数据。在患有这种联合缺损的患者中，我们发现严重肺动脉高压、多种非心脏畸形、智力发育迟缓及早期死亡率的发生率异常高。
