Mehta S K, Chakravarti R N
Am J Dig Dis. 1977 Mar;22(3):223-9. doi: 10.1007/BF01072280.
There is a lot of diversity in the observations on jejunal histology between light and discretion microscopy in tropical sprue. In order to compare the light and dissection microscopic appearances, a three-dimensional model of the villous pattern was constructed after a study of 350 serial sections of jejunal biopsy from a patient with tropical sprue. There was considerable variation in the morphological appearance of the villi in different sections. The changes seen varied from mild to partial villous atrophy. Broad synechia and bridge formation between adjoining villi due to fusion was frequently observed. It is postulated that the process of fusion of villi may be partly responsible for the development of features of partial villous atrophy seen in jejunal biopsies in tropical sprue. Normal jejunal pattern reported by some workers in patients with tropical sprue could possibly be due to inadequate sampling of the total biopsy piece.
在热带口炎性腹泻中，空肠组织学的光学显微镜观察和解剖显微镜观察存在很大差异。为了比较光学显微镜和解剖显微镜下的表现，在对一名热带口炎性腹泻患者的350个空肠活检连续切片进行研究后，构建了绒毛模式的三维模型。不同切片中绒毛的形态外观存在相当大的差异。观察到的变化从轻到部分绒毛萎缩不等。经常观察到相邻绒毛因融合而形成广泛的粘连和桥接。据推测，绒毛融合过程可能部分导致了热带口炎性腹泻空肠活检中所见的部分绒毛萎缩特征的发展。一些研究人员报告的热带口炎性腹泻患者的正常空肠模式可能是由于对整个活检组织取样不足所致。
