Mathan M M, Ponniah J, Mathan V I
Dig Dis Sci. 1986 Jun;31(6):586-92. doi: 10.1007/BF01318689.
A morphometric study confirmed that increasing severity of the jejunal mucosal morphologic lesion is accompanied by increased crypt height and reduced villus length in patients with tropical sprue. Mitotic activity in the crypts was increased. Pulse labeling of jejunal mucosal biopsies cultured in vitro with [3H]thymidine confirmed that there was increased uptake of label in tropical sprue with more rapid migration of labeled cells to the villi. The label was also lost more rapidly. Earlier ultrastructural studies have shown enterocyte damage and extrusion in the crypt and villus epithelium. The present data suggest that in the jejunal mucosa of patients with tropical sprue, the loss of damaged enterocytes leads to villus shortening and increased cell production in the crypts, with hypertrophy of the crypts.
一项形态计量学研究证实，热带口炎性腹泻患者空肠黏膜形态学病变的严重程度增加时，隐窝高度增加而绒毛长度缩短。隐窝中的有丝分裂活性增强。用[3H]胸腺嘧啶核苷对体外培养的空肠黏膜活检组织进行脉冲标记，证实热带口炎性腹泻患者对标记物的摄取增加，标记细胞向绒毛的迁移更快。标记物丢失也更快。早期的超微结构研究显示，隐窝和绒毛上皮中有肠上皮细胞损伤和脱落。目前的数据表明，在热带口炎性腹泻患者的空肠黏膜中，受损肠上皮细胞的脱落导致绒毛缩短和隐窝中细胞生成增加，同时隐窝肥大。
