Mitchell J F, Maas L C, Barger R C, Geizayd E A
Am J Hosp Pharm. 1977 Feb;34(2):171-2.
The case of a 41-year-old male with a history of multiple emboli and short bowel syndrome who was successfully anticoagulated with sodium warfarin is described. The prothrombin times were stabilized in a therapeutic range with warfarin doses of 5.0 mg -7.5 mg daily. The pharmacokinetics of warfarin suggests that absorption is high in the proximal intestine. The successful use of sodium warfarin in the patient substantiates this finding and demonstrates that short bowel does not necessarily preclude the use of warfarin for anticoagulation. It is suggested that patients with short bowel syndrome may be successfully anticoagulated with oral products; however, careful monitoring of each patient's prothrombin time is necessary because of the variability and extent of bowel loss.
本文描述了一名41岁男性患者，有多次栓塞病史和短肠综合征，使用华法林钠成功进行抗凝治疗的案例。通过每日5.0毫克至7.5毫克的华法林剂量，凝血酶原时间稳定在治疗范围内。华法林的药代动力学表明，其在近端肠道的吸收良好。该患者成功使用华法林钠证实了这一发现，并表明短肠并不一定排除使用华法林进行抗凝治疗。建议短肠综合征患者可通过口服制剂成功进行抗凝治疗；然而，由于肠道丢失的变异性和程度，需要仔细监测每位患者的凝血酶原时间。
