通过大鼠选择实验估计肌纤维组成的遗传特性。

Heredity of muscle fibre composition estimated from a selection experiment in rats.

作者信息

Nakamura T, Masui S, Wada M, Katoh H, Mikami H, Katsuta S

机构信息

Department of General Education, Osaka Institute of Technology, Japan.

出版信息

Eur J Appl Physiol Occup Physiol. 1993;66(1):85-9. doi: 10.1007/BF00863405.

DOI:10.1007/BF00863405

PMID:8425517

Abstract

The extent to which muscle fibre composition was determined by the genes transmitted from parents was estimated by using successive selections of rats. A foundation population (G0) was established to carry out the selections; it consisted of 100 albino rats which were randomly chosen from heterogeneous stock. The heterogeneous stock was produced by random-mating of three strains, Wistar-Imamichi, Fischer 344 and Donryu. Successive selection for a high percentage of slow twitch fibres (% ST) was made from G0 to the fourth generation (G4). The mean values of % ST changed from 50.0% in G0 to 55.6% in G4. The mean value in G4 was significantly higher than that in G0. The realized heritability in G0-G4 was calculated from the regression of selection response on the cumulated selection differential. The regression coefficient was 0.17 (SEM 0.04). The realized heritability was significantly different from 0 at the 0.05 level. We concluded that in rats about 17% of the variation of muscle fibre composition was determined by the genes transmitted from parents.

摘要

通过对大鼠进行连续选择，估计了父母遗传基因对肌肉纤维组成的决定程度。建立了一个基础群体（G0）来进行选择；它由100只从杂种群体中随机挑选的白化大鼠组成。杂种群体是由Wistar-Imamichi、Fischer 344和Donryu三个品系随机交配产生的。从G0到第四代（G4）对慢肌纤维高百分比（%ST）进行连续选择。%ST的平均值从G0的50.0%变为G4的55.6%。G4的平均值显著高于G0。根据选择反应对累积选择差的回归计算G0-G4的实现遗传力。回归系数为0.17（标准误0.04）。在0.05水平上，实现遗传力与0有显著差异。我们得出结论，在大鼠中，约17%的肌肉纤维组成变异是由父母遗传的基因决定的。