Fargeas M J, Fioramonti J, Bueno L
Department of Pharmacology, Institut National de la Recherche Agronomique, Toulouse, France.
Gastroenterology. 1993 Feb;104(2):377-83. doi: 10.1016/0016-5085(93)90404-z.
Interleukin 1 (IL-1) can influence gut functions by inhibiting gastric acid secretion. This study was performed to investigate the effects of IL-1 on intestinal motility and the mechanisms involved.
The effects of IL-1 beta were determined by electromyography in conscious rats with implanted electrodes and a permanent catheter in a lateral brain ventricle.
Intracerebroventricular IL-1 beta (15 ng) administered to fed rats immediately stimulated cecocolonic spike bursts and caused a migrating myoelectric complex pattern after a delay in the small intestine. Tenfold higher doses of peripherally administered IL-1 beta did not promote similar reactions. The IL-1 antagonist reduced the small intestinal effect of IL-1 beta and blocked the cecocolonic stimulation. Indomethacin and SC 19220 reduced the small intestinal effects but did not antagonize the increase in cecocolonic contractions. In contrast, alpha-helical CRF9-41 blocked the increase of cecocolonic contractions but did not antagonize the IL-1 beta-induced effects on the small intestine.
IL-1 beta's effects on intestinal motility can be mainly ascribed to a central action. The cecocolonic stimulation may be mediated by brain corticotropin-releasing factor, whereas the small intestinal effects involve a prostaglandin mediation.
白细胞介素1（IL-1）可通过抑制胃酸分泌影响肠道功能。本研究旨在探讨IL-1对肠道运动的影响及其相关机制。
通过植入电极和侧脑室永久性导管的清醒大鼠的肌电图来确定IL-1β的作用。
给进食大鼠脑室内注射IL-1β（15纳克）立即刺激盲肠结肠尖峰爆发，并在小肠延迟后引起移行性肌电复合波模式。外周给予高10倍剂量的IL-1β未促进类似反应。IL-1拮抗剂降低了IL-1β对小肠的作用并阻断了盲肠结肠刺激。吲哚美辛和SC 19220降低了小肠的作用，但未拮抗盲肠结肠收缩的增加。相反，α-螺旋促肾上腺皮质激素释放因子9-41阻断了盲肠结肠收缩的增加，但未拮抗IL-1β对小肠的作用。
IL-1β对肠道运动的影响主要归因于中枢作用。盲肠结肠刺激可能由脑促肾上腺皮质激素释放因子介导，而小肠的作用涉及前列腺素介导。
