Thomas I, Khorenian S, Arbesfeld D M
New Jersey Medical School, Newark.
J Am Acad Dermatol. 1993 Jan;28(1):74-7. doi: 10.1016/0190-9622(93)70013-j.
Although bullous pemphigoid (BP) is a benign self-limited disease, the mainstay of treatment remains systemic steroids, often in combination with immunosuppressive agents. This therapy has considerable potential toxicity, particularly in elderly patients with preexisting problems.
The purpose of this study was to evaluate the efficacy of oral tetracycline as first-choice therapy in patients with BP.
Every patient newly diagnosed with generalized BP was treated with oral tetracycline and a midpotency topical steroid.
In all five patients, blister formation was stopped and reepithelialization completed within 1 to 3 weeks. There was no relapse or toxicity noted; follow-up ranged from 16 to 24 months.
Oral tetracycline was found to be rapidly efficacious in all patients and devoid of toxicity.
尽管大疱性类天疱疮（BP）是一种良性自限性疾病，但治疗的主要方法仍然是全身使用类固醇，通常还会联合免疫抑制剂。这种疗法具有相当大的潜在毒性，尤其是在有基础疾病的老年患者中。
本研究的目的是评估口服四环素作为BP患者首选治疗方法的疗效。
每一位新诊断为泛发性BP的患者均接受口服四环素和中效外用类固醇治疗。
所有5例患者的水疱形成均在1至3周内停止，上皮再形成完成。未观察到复发或毒性反应；随访时间为16至24个月。
发现口服四环素对所有患者均迅速有效且无毒性。
