寻常型天疱疮经胃肠外金疗法导致的肝坏死。

Hepatonecrosis resulting from parenteral gold therapy in pemphigus vulgaris.

作者信息

Rye B, Krusinski P A

机构信息

Department of Medicine, Medical Center Hospital of Vermont, Burlington.

出版信息

J Am Acad Dermatol. 1993 Jan;28(1):99-101. doi: 10.1016/0190-9622(93)70019-p.

DOI:10.1016/0190-9622(93)70019-p

PMID:8425980

Abstract

A patient who had pemphigus vulgaris received therapy with gold thiomalate in addition to dexamethasone. Three weeks after the initiation of parenteral gold the patient developed acute hepatitis. Causes other than gold toxicity were ruled out, and the patient recovered completely after discontinuation of gold therapy. This is the first case of acute hepatonecrosis resulting from gold therapy of pemphigus to be reported in the dermatologic literature.

摘要

一名寻常型天疱疮患者除接受地塞米松治疗外，还接受了硫代苹果酸金钠治疗。胃肠外给予金制剂三周后，该患者出现急性肝炎。排除了金中毒以外的其他病因，停用金制剂治疗后患者完全康复。这是皮肤科文献中报道的首例因金制剂治疗天疱疮导致急性肝坏死的病例。