人类动脉粥样硬化斑块单克隆特性的影响
Implications of the monoclonal character of human atherosclerotic plaques.
作者信息
Benditt E P
出版信息
Am J Pathol. 1977 Mar;86(3):693-702.
Abstract
Evidence for the monoclonal nature of human atherosclerotic plaques is reviewed. Eighty percent of discrete raised atherosclerotic plaques are of single phenotype. Interpretations alternative to single-cell orgin, based on patch size, selection due to linked genes, or repetitive sampling do not seem to explain the apparent monoclonality. Search for carriers in serum of mutagens, such as may be present in cigarette smoke, show them to be the lipoproteins, and the presence and possible role of intrinsic mutagens, e.g., cholesterol-alpha-oxide, are presented. The possible role for other factors implied by the monoclonal hypothesis, e.g., the mechanism by which estrogen therapy may increase coronary attacks, is discussed.
摘要
本文综述了人类动脉粥样硬化斑块单克隆性质的证据。80%的离散性隆起动脉粥样硬化斑块具有单一表型。基于斑块大小、连锁基因选择或重复采样等单细胞起源以外的解释，似乎无法解释明显的单克隆性。对血清中诱变剂携带者的研究，如香烟烟雾中可能存在的诱变剂，表明它们是脂蛋白，并介绍了内源性诱变剂（如胆固醇-α-氧化物）的存在及其可能作用。讨论了单克隆假说所暗示的其他因素的可能作用，例如雌激素治疗可能增加冠心病发作的机制。
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本文引用的文献
1
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Proc Natl Acad Sci U S A. 1963 Sep;50(3):481-5. doi: 10.1073/pnas.50.3.481.
2
Production of ulcerated atherosclerotic lesions in cockerels.
Circ Res. 1962 Nov;11:811-9. doi: 10.1161/01.res.11.5.811.
3
The normal human female as a mosaic of X-chromosome activity: studies using the gene for C-6-PD-deficiency as a marker.作为X染色体活性嵌合体的正常人类女性：以C-6-PD缺乏症基因作为标记的研究
Proc Natl Acad Sci U S A. 1962 Jan 15;48(1):9-16. doi: 10.1073/pnas.48.1.9.
4
The role of smooth muscle cells in the fibrogenesis of arteriosclerosis.平滑肌细胞在动脉硬化纤维化形成中的作用。
Am J Pathol. 1960 Oct;37(4):377-89.
5
The fine structure of human atherosclerotic lesions.人类动脉粥样硬化病变的精细结构。
Am J Pathol. 1961 Mar;38(3):263-87.
6
Isolation and identification of cholesterol -oxide and other minor sterols in human serum.人血清中胆固醇氧化物及其他微量固醇的分离与鉴定
Lipids. 1971 Nov;6(11):836-43. doi: 10.1007/BF02531214.
7
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8
9
Studies on human placental carbon monoxide-binding cytochromes.人胎盘一氧化碳结合细胞色素的研究。
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10
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Exp Mol Pathol. 1976 Apr;24(2):244-60. doi: 10.1016/0014-4800(76)90009-5.
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