Benditt E P
Am J Pathol. 1977 Mar;86(3):693-702.
Evidence for the monoclonal nature of human atherosclerotic plaques is reviewed. Eighty percent of discrete raised atherosclerotic plaques are of single phenotype. Interpretations alternative to single-cell orgin, based on patch size, selection due to linked genes, or repetitive sampling do not seem to explain the apparent monoclonality. Search for carriers in serum of mutagens, such as may be present in cigarette smoke, show them to be the lipoproteins, and the presence and possible role of intrinsic mutagens, e.g., cholesterol-alpha-oxide, are presented. The possible role for other factors implied by the monoclonal hypothesis, e.g., the mechanism by which estrogen therapy may increase coronary attacks, is discussed.
本文综述了人类动脉粥样硬化斑块单克隆性质的证据。80%的离散性隆起动脉粥样硬化斑块具有单一表型。基于斑块大小、连锁基因选择或重复采样等单细胞起源以外的解释，似乎无法解释明显的单克隆性。对血清中诱变剂携带者的研究，如香烟烟雾中可能存在的诱变剂，表明它们是脂蛋白，并介绍了内源性诱变剂（如胆固醇-α-氧化物）的存在及其可能作用。讨论了单克隆假说所暗示的其他因素的可能作用，例如雌激素治疗可能增加冠心病发作的机制。
