不可切除胰腺腺癌术中放疗联合热疗的初步生存报告
Preliminary survivorship report on combined intraoperative radiation and hyperthermia treatments for unresectable pancreatic adenocarcinoma.
作者信息
Ashayeri E, Bonney G, DeWitty R L, Goldson A L, Leffall L D, Thomas J N
机构信息
Department of Radiation Oncology, Howard University Hospital, Washington, DC 20060.
出版信息
J Natl Med Assoc. 1993 Jan;85(1):36-40.
Abstract
Five patients with unresectable pancreatic adenocarcinoma were treated with simultaneous intraoperative radiotherapy and intraoperative hyperthermia. Postoperative survivorship averaged 15.8 months, which compares favorably to a previous study in which 19 patients receiving intraoperative radiotherapy without intraoperative hyperthermia survived an average of 6.05 months. Three of the five patients following the experimental protocol of intraoperative radiotherapy and intraoperative hyperthermia with additional external beam radiotherapy are still alive, which may result in average postoperative survivorship exceeding 15.8 months.
摘要
五名无法切除的胰腺腺癌患者接受了术中同步放疗和术中热疗。术后平均生存期为15.8个月，与之前一项研究相比结果良好，在该研究中，19名接受术中放疗但未接受术中热疗的患者平均存活6.05个月。按照术中放疗和术中热疗并额外进行外照射放疗的实验方案治疗的五名患者中有三名仍然存活，这可能会使术后平均生存期超过15.8个月。
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本文引用的文献
1
Intraoperative radiotherapy for advanced carcinoma of the pancreas.
Cancer. 1984 Dec 1;54(11):2375-84. doi: 10.1002/1097-0142(19841201)54:11<2375::aid-cncr2820541112>3.0.co;2-h.
2
Clinical hyperthermia: results of a phase I trial employing hyperthermia alone or in combination with external beam or interstitial radiotherapy.临床热疗：一项I期试验的结果，该试验单独使用热疗或联合外照射或组织间放疗。
Cancer. 1982 Jan 15;49(2):205-16. doi: 10.1002/1097-0142(19820115)49:2<205::aid-cncr2820490202>3.0.co;2-w.
3
Single high dose intraoperative electrons for advanced stage pancreatic cancer: phase I pilot study.晚期胰腺癌术中单次大剂量电子线照射：I期初步研究
Int J Radiat Oncol Biol Phys. 1981 Jul;7(7):869-74. doi: 10.1016/0360-3016(81)90002-x.
4
Hyperthermia: its effect on proliferative and plateau phase cell cultures.热疗：其对增殖期和平稳期细胞培养的影响。
Radiology. 1974 Oct;113(1):209-11. doi: 10.1148/113.1.209.
5
Site and disease selection for hyperthermia clinical trials.
Int J Hyperthermia. 1986 Apr-Jun;2(2):139-56. doi: 10.3109/02656738609012390.
6
Cancer of the pancreas. 50 years of surgery.胰腺癌。50年的外科治疗历程。
Cancer. 1987 Nov 1;60(9):2284-303. doi: 10.1002/1097-0142(19871101)60:9<2284::aid-cncr2820600930>3.0.co;2-v.
7
Treatment of unresectable pancreatic carcinoma using irradiation with concurrent intravenous 5-FU infusion therapy.采用放疗联合静脉输注5-氟尿嘧啶疗法治疗不可切除的胰腺癌。
Cancer Invest. 1988;6(3):263-6. doi: 10.3109/07357908809080647.
8
Combined modality treatment of localized unresectable adenocarcinoma of the pancreas.局部不可切除胰腺癌的综合治疗
Int J Radiat Oncol Biol Phys. 1988 Jan;14(1):79-84. doi: 10.1016/0360-3016(88)90054-5.
9
Intraoperative and external beam irradiation +/- 5-FU for locally advanced pancreatic cancer.
Int J Radiat Oncol Biol Phys. 1987 Mar;13(3):319-29. doi: 10.1016/0360-3016(87)90005-8.
10
[Studies on treatment results and prognostic factors of intraoperative radiotherapy in pancreatic carcinoma].[胰腺癌术中放疗的治疗效果及预后因素研究]
Nihon Igaku Hoshasen Gakkai Zasshi. 1989 May 25;49(5):614-21.
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