Thomas M R, Ulrichsen R F, Calaresu F R
Am J Physiol. 1977 Feb;232(2):H157-66. doi: 10.1152/ajpheart.1977.232.2.H157.
The role of the lateral reticular nucleus (LRN) in central cardiovascular regulation was investigated in cats. In 15 cerebellectomized and nine intact chloralosed cats stimulation of 115 histologically verified sites in the LRN elicited increases in arterial pressure and heart rate; the latter was abolished by propranolol but not by bilateral cervical vagotomy. The pressor response was significantly greater in intact animals. Electrical activity was recorded from the right inferior cardiac nerve (ICN) during stimulation fo the LRN and of a vasomotor region in the posteromedial hypothalamus (PMH). Stimulation of sites in the LRN and in the PMH, on both sides, elicited a response in the right ICN that was consistently abolished during baroreceptor excitation. Medullary transection 3 mm rostral to the LRN did not abolish the ICN response to LRN stimulation. The conclusions are drawn that stimulation of the LRN elicits cardiovascular responses probably due to excitation of groups of neurons in this nucleus located in a descending sympathetic pathway originating in the PMH and that these responses can be inhibited by excitation of baroreceptors. In view of the known functional connections of the LRN with the somatomotor system it is suggested that this nucleus may play a major role in somatosympathetic reflexes.
在猫身上研究了外侧网状核（LRN）在中枢心血管调节中的作用。在15只小脑切除的猫和9只完整的水合氯醛麻醉猫中，刺激LRN中115个经组织学证实的位点会引起动脉血压和心率升高；后者可被普萘洛尔消除，但双侧颈迷走神经切断术不能消除。完整动物的升压反应明显更大。在刺激LRN和下丘脑后内侧（PMH）的血管运动区域时，记录右侧下心神经（ICN）的电活动。双侧刺激LRN和PMH中的位点会在右侧ICN中引发一种反应，这种反应在压力感受器兴奋时始终会被消除。在LRN上方3毫米处进行延髓横断术并不能消除ICN对LRN刺激的反应。得出的结论是，刺激LRN会引发心血管反应，这可能是由于该核中位于起源于PMH的下行交感神经通路中的神经元群受到兴奋所致，并且这些反应可被压力感受器的兴奋所抑制。鉴于LRN与躯体运动系统已知的功能联系，有人提出该核可能在躯体交感反射中起主要作用。
