Rosenfeld C R
Am J Physiol. 1977 Mar;232(3):H231-5. doi: 10.1152/ajpheart.1977.232.3.H231.
Cardiac output and organ blood flows were measured in 6 nonpregnant and 24 pregnant ewes from 38 to 141 days of gestation employing radionuclide-labeled microspheres. From the nonpregnant state to term increases in cardiac output, from 73.7 +/- 4.6 ml/min-kg of maternal weight to 148 +/- 2.4 ml/min-kg, and heart rate, from 88.5 +/- 10.3 to 106 +/- 4.6 beats/min, were noted, while mean arterial blood pressure was unchanged. Near term, the blood flows to the uterus and mammary gland represented approximately 18% of cardiac output. The blood flow to nonreproductive organs increased from 76.6 +/- 6.8 ml/min-kg of nonreproductive tissue in the nonpregnant state to 132 +/- 3.5 ml/min-kg at 130-140 days' gestation (P less than 0.01). No significant changes in renal blood flow were detected.
在妊娠38至141天的6只未孕母羊和24只孕羊中，采用放射性核素标记微球测量心输出量和器官血流量。从非孕状态到足月，心输出量从每千克母羊体重73.7±4.6毫升/分钟增加到148±2.4毫升/分钟，心率从88.5±10.3次/分钟增加到106±4.6次/分钟，而平均动脉血压未变。接近足月时，流向子宫和乳腺的血流量约占心输出量的18%。流向非生殖器官的血流量从非孕状态下每千克非生殖组织76.6±6.8毫升/分钟增加到妊娠130 - 140天时的132±3.5毫升/分钟（P<0.01）。未检测到肾血流量有显著变化。
