Rosenfeld C R, Worley R J
Am J Obstet Gynecol. 1978 Feb 15;130(4):385-90. doi: 10.1016/0002-9378(78)90277-6.
The effects of systemic infusions of dehydroisoandrosterone (6 mg.) on endogenous estrogen production and subsequent changes in regional blood flows and cardiac output were studied in six pregnant ewes at 105 to 128 days of gestation. Blood flows were measured with radionuclide-labeled microspheres. Plasma estrone concentrations increased from (mean +/- S.E.M.*) 27 +/- 2 to 117 +/- 13 pg. per mililiter, while estrodiol rose from 34 +/- 5 to 72 +/- 5 pg. per mililiter (p less than 0.05). Associated increases in blood flow occurred in endometrium, myometrium, and unimplanted uterine caruncles, while blood flow to the placental cotyledons was not significiantly changed. Perfusion was also increased in the Fallopian tubes, mammary gland, cervix, and vagina, the greatest fractional increase in blood flow occurring in the latter two, 387 and 456 per cent (p less than 0.005), respectively.
在妊娠105至128天的6只怀孕母羊中，研究了静脉输注脱氢表雄酮（6毫克）对内源性雌激素生成以及随后局部血流和心输出量变化的影响。采用放射性核素标记微球测量血流量。血浆雌酮浓度从（均值±标准误*）每毫升27±2皮克升至117±13皮克，而雌二醇从每毫升34±5皮克升至72±5皮克（p<0.05）。子宫内膜、子宫肌层和未着床的子宫肉阜的血流量相应增加，而胎盘小叶的血流量无显著变化。输卵管、乳腺、子宫颈和阴道的灌注也增加，后两者的血流量增加比例最大，分别为387%和456%（p<0.005）。
