儿童脑膜瘤：磁共振成像和组织病理学表现
Meningiomas in children: MR and histopathologic findings.
作者信息
Glasier C M, Husain M M, Chadduck W, Boop F A
机构信息
Department of Radiology, Arkansas Children's Hospital, Little Rock 72202.
出版信息
AJNR Am J Neuroradiol. 1993 Jan-Feb;14(1):237-41.
PURPOSE
To present the MR and histopathologic findings in five children with meningiomas.
METHODS
Five children aged 3 months to 16 years with pathologically proved meningiomas underwent preoperative contrast enhanced MR. Tissue in four patients was sent for chromosomal analysis in addition to routine histopathologic studies.
RESULTS
All five tumors were extra-axial, two supratentorial and three in the posterior fossa. MR showed variable signal intensity on precontrast T1-weighted images. All of the tumors were hyperintense on proton density- and T2-weighted images and showed intense contrast enhancement. Histopathologic analysis showed two meningotheliomatous, one transitional, one chordoid, and one hemangiopericytic variant of meningioma. Chromosomal analysis showed deletions involving chromosome 22 in two of four tumors studied.
CONCLUSION
Meningiomas in children have a higher incidence of posterior fossa location and different histologic types than seen in adults. MR showed the tumors in our patients to be extra-axial, hyperintense on proton density- and T2-weighted images with intense enhancement on postcontrast T1-weighted images. Chromosomal aberrations were noted in two patients.
目的
介绍5例儿童脑膜瘤的磁共振成像（MR）及组织病理学表现。
方法
5例年龄在3个月至16岁之间、经病理证实为脑膜瘤的儿童患者接受了术前增强磁共振成像检查。除常规组织病理学研究外，4例患者的组织还送去进行染色体分析。
结果
所有5个肿瘤均位于脑外，2个位于幕上，3个位于后颅窝。磁共振成像在对比剂增强前的T1加权图像上显示出不同的信号强度。所有肿瘤在质子密度加权像和T2加权像上均为高信号，并显示出明显的对比剂增强。组织病理学分析显示2例为脑膜皮型、1例为过渡型、1例为脊索样型、1例为血管外皮型脑膜瘤。染色体分析显示，在研究的4个肿瘤中有2个存在涉及22号染色体的缺失。
结论
儿童脑膜瘤后颅窝位置的发生率及组织学类型与成人不同。磁共振成像显示我们的患者肿瘤位于脑外，在质子密度加权像和T2加权像上为高信号，在对比剂增强后的T1加权像上有明显强化。2例患者存在染色体畸变。
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