Lindsley C B
Department of Pediatrics, University of Kansas Medical Center, Kansas City 66160-7330.
Am J Dis Child. 1993 Feb;147(2):229-36. doi: 10.1001/archpedi.1993.02160260119038.
Nonsteroidal anti-inflammatory drugs have an expanding role in pediatrics. The indications include (1) treatment of childhood rheumatic disease and other chronic inflammatory conditions; (2) symptomatic treatment of clinical problems such as fever, musculoskeletal pain, or dysmenorrhea; and (3) induction of closure of patent ductus arteriosus. Nonsteroidal anti-inflammatory drugs are generally well tolerated with a low incidence of serious side effects. However, potentially serious gastrointestinal, hepatic, central nervous system, and renal adverse effects have occurred. The pediatrician should be familiar with the pharmacokinetics and dosages of the various nonsteroidal anti-inflammatory drugs as well as laboratory tests necessary to monitor their use. Guidelines are suggested.
非甾体抗炎药在儿科领域的应用日益广泛。其适应证包括：（1）治疗儿童风湿性疾病及其他慢性炎症性疾病；（2）对发热、肌肉骨骼疼痛或痛经等临床问题进行对症治疗；（3）促使动脉导管未闭闭合。非甾体抗炎药一般耐受性良好，严重副作用发生率较低。然而，仍有可能发生潜在的严重胃肠道、肝脏、中枢神经系统和肾脏不良反应。儿科医生应熟悉各类非甾体抗炎药的药代动力学、剂量以及监测其使用所需的实验室检查。现提出相关指导原则。
