Aranda Jacob V, Beharry Kay D, Valencia Gloria B
State University of New York Downstate Medical Center, Brooklyn, NY, USA.
J Matern Fetal Neonatal Med. 2009;22 Suppl 3:21-2. doi: 10.1080/14767050903194461.
To determine which nonsteroidal anti-inflammatory drugs (NSAIDs) are being used in newborns.
NSAID use was examined in local neonatal units and in published literature indexed by PubMed.
Various NSAIDs are being used in newborns. Indomethacin and ibuprofen are used worldwide for closure of patent ductus arteriosus (PDA). Both have been tested in randomized clinical trials and are approved by FDA and EMEA for PDA closure in newborns. Indomethacin, but not ibuprofen is used for prevention of intraventricular hemorrhage (IVH). Ketorolac is being studied as a potential parenteral analgesic and as a topical drug for prevention of oxygen-induced retinopathy. Others are associated with severe adverse events.
NSAIDs remain as active drugs used for PDA closure and IVH prevention. Potential uses including analgesia and retinopathy prevention are currently being studied.
确定哪些非甾体抗炎药（NSAIDs）正在新生儿中使用。
在当地新生儿病房以及由PubMed索引的已发表文献中对NSAIDs的使用情况进行了研究。
多种NSAIDs正在新生儿中使用。吲哚美辛和布洛芬在全球范围内用于动脉导管未闭（PDA）的闭合。两者均已在随机临床试验中进行了测试，并获得了美国食品药品监督管理局（FDA）和欧洲药品管理局（EMEA）的批准，用于新生儿PDA的闭合。吲哚美辛用于预防脑室内出血（IVH），而布洛芬则不用于此。酮咯酸正在作为一种潜在的胃肠外镇痛药以及预防氧诱导性视网膜病变的局部用药进行研究。其他药物则与严重不良事件相关。
NSAIDs仍然是用于PDA闭合和预防IVH的常用药物。目前正在研究其包括镇痛和预防视网膜病变在内的潜在用途。
