Kolodziej M
Hematology-Oncology Section, Hospital of the University of Pennsylvania, Philadelphia.
Am J Med Sci. 1993 Feb;305(2):101-2. doi: 10.1097/00000441-199302000-00007.
Thrombotic thrombocytopenic purpura is a clinical syndrome defined by the pentad of thrombocytopenia, microangiopathic hemolytic anemia, fever, and renal and neurologic abnormalities. The pathogenesis of this syndrome remains enigmatic, though appropriate management usually involves plasma administration. The authors report on an alternative therapy, high-dose intravenous immunoglobulin, used in the patient after the failure of plasmapheresis. The implications and potential applications of this therapy are discussed.
血栓性血小板减少性紫癜是一种临床综合征，其定义为血小板减少、微血管病性溶血性贫血、发热以及肾脏和神经异常这五联征。尽管该综合征的发病机制仍不明确，但适当的治疗通常包括输注血浆。作者报告了一种替代疗法，即血浆置换失败后在患者中使用大剂量静脉注射免疫球蛋白。并讨论了该疗法的意义和潜在应用。
