Rodriguez A, Bustos-Obregón E
Department of Experimental Morphology, University of Chile, Medical School, Santiago.
Andrologia. 1993 Jan-Feb;25(1):29-37. doi: 10.1111/j.1439-0272.1993.tb02678.x.
The post-natal growth and differentiation of the vas deferens was studied in rats aged 1-180 d by light, and with transmission electron microscopy in parallel with a radioimmunoassay of serum testosterone. During the first week and the major part of the second week of the post-natal life the vas deferens presented embryological features. Differentiation of the proximal and distal segments of the vas started 12 d after birth. At 25 d, the epithelium of the mucosa in the distal segment already showed some adult histologic characteristics. The weight notably increased between 1 and 45 d and the higher rates of growth of their histologic components occurred until 45 or 60 d, in parallel to testosterone serum levels. These results suggest that growth and differentiation of the vas deferens are androgen-dependent events and precede the end of the first spermatogenic cycle, assuring the viability of spermatozoa that will enter the duct.
通过光学显微镜以及透射电子显微镜，同时结合血清睾酮放射免疫测定法，对1至180日龄大鼠输精管的出生后生长和分化进行了研究。在出生后的第一周以及第二周的大部分时间里，输精管呈现出胚胎学特征。输精管近端和远端的分化在出生后12天开始。在25天时，远端段黏膜的上皮已经显示出一些成年期的组织学特征。重量在1至45天之间显著增加，其组织学成分的较高生长速率一直持续到45或60天，这与血清睾酮水平平行。这些结果表明，输精管的生长和分化是雄激素依赖性事件，并且发生在第一个生精周期结束之前，确保进入管道的精子的活力。
