Iwata Y, Nakamura H, Fujiwara K, Shigekawa M
Department of Molecular Physiology, National Cardiovascular Center Research Institute, Osaka, Japan.
Biochem Biophys Res Commun. 1993 Jan 29;190(2):589-95. doi: 10.1006/bbrc.1993.1089.
In the ventricular muscle from 30- to 40-day-old Bio 14.6 cardiomyopathic hamsters, the concentration of dystrophin was about 50% less than the normal controls. Despite its reduced content, extraction of dystrophin from the myopathic muscle into the microsomal fraction was threefold higher as compared to the control. These results suggest that abnormality exists in the association of dystrophin with sarcolemmal membranes in the myopathic muscle. No obvious difference, however, was observed between normal and myopathic myocytes in their immunofluorescence staining patterns.
在30至40日龄的Bio 14.6心肌病仓鼠的心室肌中，抗肌萎缩蛋白的浓度比正常对照组低约50%。尽管其含量降低，但与对照组相比，从病变肌肉中提取到微粒体部分的抗肌萎缩蛋白高出三倍。这些结果表明，病变肌肉中抗肌萎缩蛋白与肌细胞膜的结合存在异常。然而，正常和病变心肌细胞在免疫荧光染色模式上未观察到明显差异。
