Keating M J
MD Anderson Cancer Center, Houston, Texas.
Curr Opin Oncol. 1993 Jan;5(1):35-41.
A consistent stimulus to increase interest in malignant disease is the discovery of new successful treatments. The dramatic activity of the nucleoside analogues, 2'-deoxycoformycin, fludarabine, and 2-chlorodeoxyadenosine, in indolent lymphoproliferative diseases has caused a reawakening of interest in the biology and treatment of chronic lymphocytic leukemia and hairy-cell leukemia. The high response rate has led to a reevaluation of criteria for response in these diseases as well as indications for treatment and prognostic factors.
对恶性疾病兴趣增加的一个持续刺激因素是发现新的成功治疗方法。核苷类似物2'-脱氧助间型霉素、氟达拉滨和2-氯脱氧腺苷在惰性淋巴细胞增殖性疾病中的显著活性，已引起人们对慢性淋巴细胞白血病和毛细胞白血病的生物学及治疗的兴趣再度觉醒。高缓解率促使人们重新评估这些疾病的缓解标准以及治疗指征和预后因素。
