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1
High levels of circulating soluble receptors for tumor necrosis factor in hairy cell leukemia and type B chronic lymphocytic leukemia.毛细胞白血病和B型慢性淋巴细胞白血病中高水平的循环肿瘤坏死因子可溶性受体
J Clin Invest. 1992 May;89(5):1690-3. doi: 10.1172/JCI115769.
2
Leukemic cells in hairy cell leukemia and B cell chronic lymphocytic leukemia release soluble TNF receptors.毛细胞白血病和B细胞慢性淋巴细胞白血病中的白血病细胞会释放可溶性肿瘤坏死因子受体。
Leukemia. 1995 Jun;9(6):1051-5.
3
IFN-alpha in vivo enhances tumor necrosis factor receptor levels on hairy cells.
J Immunol. 1990 Sep 15;145(6):1713-8.
4
B lymphocytes from patients with chronic lymphoproliferative disorders are equipped with different costimulatory molecules.慢性淋巴细胞增殖性疾病患者的B淋巴细胞具有不同的共刺激分子。
Cancer Res. 1997 Nov 1;57(21):4940-7.
5
Effects of tumour necrosis factor and alpha interferon on chronic B cell malignancies.肿瘤坏死因子和α干扰素对慢性B细胞恶性肿瘤的影响。
Nouv Rev Fr Hematol (1978). 1988;30(5-6):317-9.
6
Purine metabolism enzymes and immunological phenotype in chronic B-cell malignancies: chronic lymphocytic leukemia, prolymphocytic leukemia and hairy cell leukemia.慢性B细胞恶性肿瘤中的嘌呤代谢酶与免疫表型：慢性淋巴细胞白血病、幼淋巴细胞白血病和毛细胞白血病
Neoplasma. 1990;37(6):693-701.
7
The soluble interleukin-2 receptor: a new humoral marker in hematological malignancies.
Acta Haematol Pol. 1991;22(2):327-30.
8
Reconstitution of endogenous interferon a by recombinant interferon in hairy cell leukemia.重组干扰素在毛细胞白血病中对内源性干扰素α的重建作用
Cancer Res. 2000 Oct 1;60(19):5420-6.
9
[Review of relationship between tumor necrosis factor genetic polymorphism and hematological malignancies].[肿瘤坏死因子基因多态性与血液系统恶性肿瘤关系的综述]
Ai Zheng. 2003 Feb;22(2):216-20.
10
Hairy cell leukemia, a B-cell neoplasm that is particularly sensitive to the cytotoxic effect of anti-Tac(Fv)-PE38 (LMB-2).毛细胞白血病，一种对抗Tac（Fv）-PE38（LMB-2）的细胞毒性作用特别敏感的B细胞肿瘤。
Clin Cancer Res. 2000 Feb;6(2):693-700.

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1
Tumor Cell Survival Factors and Angiogenesis in Chronic Lymphocytic Leukemia: How Hot Is the Link?慢性淋巴细胞白血病中的肿瘤细胞存活因子与血管生成：二者关联有多紧密？
Cancers (Basel). 2024 Dec 29;17(1):72. doi: 10.3390/cancers17010072.
2
Clinico-Biological Implications of Modified Levels of Cytokines in Chronic Lymphocytic Leukemia: A Possible Therapeutic Role.慢性淋巴细胞白血病中细胞因子水平改变的临床生物学意义：一种可能的治疗作用
Cancers (Basel). 2020 Feb 24;12(2):524. doi: 10.3390/cancers12020524.
3
Tumor necrosis factor receptor signaling is a driver of chronic lymphocytic leukemia that can be therapeutically targeted by the flavonoid wogonin.肿瘤坏死因子受体信号转导是慢性淋巴细胞白血病的驱动因素，类黄酮染料木黄酮可通过其靶向进行治疗。
Haematologica. 2018 Apr;103(4):688-697. doi: 10.3324/haematol.2017.177808. Epub 2018 Jan 11.
4
TNF ligands and receptors--a matter of life and death.肿瘤坏死因子配体与受体——生死攸关之事。
Br J Pharmacol. 2002 Feb;135(4):855-75. doi: 10.1038/sj.bjp.0704549.
5
Kinetics of serum soluble tumour necrosis factor receptor (TNF-R) type-I and type-II after a single interferon-alpha (IFN-alpha) injection in chronic hepatitis C.慢性丙型肝炎患者单次注射α干扰素后血清Ⅰ型和Ⅱ型可溶性肿瘤坏死因子受体（TNF-R）的动力学
Clin Exp Immunol. 1999 Sep;117(3):556-60. doi: 10.1046/j.1365-2249.1999.00992.x.
6
Multifaceted inhibition of anti-tumour immune mechanisms by soluble tumour necrosis factor receptor type I.可溶性I型肿瘤坏死因子受体对抗肿瘤免疫机制的多方面抑制作用
Immunology. 1998 May;94(1):88-93. doi: 10.1046/j.1365-2567.1998.00481.x.
7
The effects of treatment with chemotherapy on energy metabolism and inflammatory mediators in small-cell lung carcinoma.化疗对小细胞肺癌能量代谢及炎症介质的影响。
Br J Cancer. 1997;76(12):1630-5. doi: 10.1038/bjc.1997.608.
8
Increased release of the tumour necrosis factor receptor p75 by immortalized human keratinocytes results from an activated shedding mechanism and is not related to augmented steady-state levels of p75 mRNA.
Arch Dermatol Res. 1996 Oct;288(11):691-6. doi: 10.1007/BF02505279.
9
The 55-kD tumor necrosis factor receptor on human keratinocytes is regulated by tumor necrosis factor-alpha and by ultraviolet B radiation.人角质形成细胞上的55-kD肿瘤坏死因子受体受肿瘤坏死因子-α和紫外线B辐射调控。
J Clin Invest. 1993 Jul;92(1):462-70. doi: 10.1172/JCI116589.
10
Relationship between soluble tumor necrosis factor (TNF) receptors and TNF alpha during immunotherapy with interleukin-2 and/or interferon alpha.白细胞介素-2和/或干扰素α免疫治疗期间可溶性肿瘤坏死因子（TNF）受体与TNFα之间的关系
Cancer Immunol Immunother. 1994 Feb;38(2):113-8. doi: 10.1007/BF01526206.

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毛细胞白血病和B型慢性淋巴细胞白血病中高水平的循环肿瘤坏死因子可溶性受体

High levels of circulating soluble receptors for tumor necrosis factor in hairy cell leukemia and type B chronic lymphocytic leukemia.

作者信息

Digel W, Porzsolt F, Schmid M, Herrmann F, Lesslauer W, Brockhaus M

机构信息

Department of Internal Medicine III, University of Ulm, Federal Republic of Germany.

出版信息

J Clin Invest. 1992 May;89(5):1690-3. doi: 10.1172/JCI115769.

DOI:10.1172/JCI115769
PMID:1314854
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC443049/
Abstract

The presence of soluble tumor necrosis factor (TNF) binding proteins (BP) was investigated in the sera of healthy volunteer blood donors and cancer patients. Two distinct types of TNFBP, types A and B, which are immunologically related to the cellular 75-kD TNF receptor (TNFR) and the cellular 55-kD TNFR, respectively, were assessed by immunoassays using nonblocking anti-receptor antibodies and 125I-recombinant human TNF alpha. As compared to the titers observed in 25 healthy controls, TNFBP types A and B titers were found to be elevated in almost all sera obtained from patients with underlying malignant disease. The highest amounts of TNFBP were seen in the sera of patients with B cell malignancies including hairy cell leukemia (HCL) and type B chronic lymphocytic leukemia. Treatment of HCL patients with recombinant human interferon-alpha was associated with decrease of circulating TNFBP.

摘要

在健康志愿者献血者和癌症患者的血清中研究了可溶性肿瘤坏死因子（TNF）结合蛋白（BP）的存在情况。使用非阻断性抗受体抗体和125I重组人TNFα，通过免疫测定法评估了两种不同类型的TNFBP，即A 型和B型，它们分别与细胞75-kD TNF受体（TNFR）和细胞55-kD TNFR在免疫学上相关。与25名健康对照者中观察到的滴度相比，在几乎所有患有潜在恶性疾病患者的血清中，A 型和B型TNFBP滴度均升高。在包括毛细胞白血病（HCL）和B型慢性淋巴细胞白血病在内的B细胞恶性肿瘤患者的血清中，TNFBP含量最高。用重组人干扰素-α治疗HCL患者与循环TNFBP的减少有关。