Vollenweider Roten S, Delozier-Blanchet C D, Masouyé I, Saurat J H
Department of Dermatology, University Hospital, Geneva, Switzerland.
Dermatology. 1993;186(2):138-43. doi: 10.1159/000247325.
We report the case of a 17-year-old girl with a constitutional chromosome anomaly (ring chromosome 7), associated with multiple pigmented skin lesions, who developed malignant melanoma. Eight other cases of ring chromosome 7 are described in the literature; all present vascular or pigmented skin lesions, but our patient was the first to develop a malignant tumor. Genetic studies in malignant melanoma are discussed, as well as the possible link between a constitutional anomaly of chromosome 7 and the occurrence of malignant melanoma. This association is possibly not fortuitous, particularly since most ring chromosome 7 patients reported to date have pigmented skin lesions.
