Cuccaro M L, Wright H H, Abramson R K, Marsteller F A, Valentine J
William S. Hall Psychiatric Institute, Columbia, South Carolina.
J Neuropsychiatry Clin Neurosci. 1993 Winter;5(1):94-101. doi: 10.1176/jnp.5.1.94.
The relationship between cognitive-intellectual abilities and whole-blood serotonin (5-hydroxytryptamine; 5-HT) in 18 autistic probands and their first-degree relatives (n = 21 parents, n = 13 siblings) was investigated. Whole-blood 5-HT was significantly negatively associated with verbal-expressive/symbolic abilities for the entire sample. The proportion of variance in cognitive-intellectual performances attributable to whole-blood 5-HT was substantial in the context of variance attributable to familial classification. The relationship between verbal-expressive abilities and whole-blood 5-HT, adjusted for race and familial classification, was noteworthy. Simple correlations between 5-HT and cognitive-intellectual performances were conducted. However, bias related to covariance attributable to race seriously limits such findings. The issue of bias and its relevance to previous research is discussed further.
对18名自闭症先证者及其一级亲属（21名父母、13名兄弟姐妹）的认知智力能力与全血血清素（5-羟色胺；5-HT）之间的关系进行了研究。全血5-HT与整个样本的言语表达/符号能力显著负相关。在归因于家族分类的方差背景下，全血5-HT在认知智力表现中所占的方差比例相当大。在对种族和家族分类进行调整后，言语表达能力与全血5-HT之间的关系值得注意。对5-HT与认知智力表现之间进行了简单相关性分析。然而，种族导致的协方差偏差严重限制了这些研究结果。进一步讨论了偏差问题及其与先前研究的相关性。
