Cook E H, Leventhal B L, Heller W, Metz J, Wainwright M, Freedman D X
Department of Child and Adolescent Psychiatry, University of Chicago, IL 60637.
J Neuropsychiatry Clin Neurosci. 1990 Summer;2(3):268-74. doi: 10.1176/jnp.2.3.268.
Whole-blood serotonin (5-HT) and plasma norepinephrine (NE) were studied in 16 autistic children, 21 siblings of autistic children, and 53 parents of autistic children. Both plasma NE and whole-blood 5-HT were negatively correlated with vocabulary performance. Whole-blood 5-HT and plasma NE did not differ between autistic children with or without histories of self-injurious behavior or decreased pain sensitivity. Eighteen subjects were hyperserotonemic (whole-blood 5-HT greater than 270 ng/ml). For these subjects, plasma NE was significantly higher than for subjects without hyperserotonemia. Seven of 10 families with one hyperserotonemic member had two or more hyperserotonemic members. Observations of familiarity of whole-blood 5-HT suggest that larger-scale and more focused study of whole-blood 5-HT as a possible genetic marker may be productive.
对16名自闭症儿童、21名自闭症儿童的兄弟姐妹以及53名自闭症儿童的父母进行了全血血清素（5-羟色胺，5-HT）和血浆去甲肾上腺素（NE）的研究。血浆NE和全血5-HT均与词汇表现呈负相关。有或无自伤行为史或疼痛敏感性降低的自闭症儿童之间，全血5-HT和血浆NE并无差异。18名受试者血清素水平过高（全血5-HT大于270 ng/ml）。对于这些受试者，其血浆NE显著高于非高血清素血症受试者。在10个有一名高血清素血症成员的家庭中，有7个家庭有两名或更多高血清素血症成员。对全血5-HT相似性的观察表明，将全血5-HT作为一种可能的遗传标记进行更大规模、更有针对性的研究可能会有所收获。
