Chapman J, Maayan C, Michaelson D M
Department of Biochemistry, George S. Wise Faculty of Life Sciences, Tel-Aviv University, Ramat Aviv, Israel.
Int Arch Allergy Immunol. 1993;100(1):42-6. doi: 10.1159/000236385.
Sera from familial dysautonomia patients are shown to contain high levels of antibodies to human serum albumin (HSA). The individual levels of anti-HSA antibodies correlate significantly with the levels of antibodies to bovine serum albumin and lactalbumin. These results and the findings that the anti-HSA level declines exponentially with age indicate that anti-HSA antibodies may be induced by aspiration of bovine milk antigens in infancy. The titer of the anti-HSA autoantibodies presently described (> 1:10,000) is much higher than those found in other diseases and may contribute to the pathological changes in familial dysautonomia.
家族性自主神经功能异常患者的血清显示含有高水平的抗人血清白蛋白（HSA）抗体。抗HSA抗体的个体水平与抗牛血清白蛋白和乳白蛋白抗体的水平显著相关。这些结果以及抗HSA水平随年龄呈指数下降的发现表明，抗HSA抗体可能是由婴儿期吸入牛乳抗原诱导产生的。目前所描述的抗HSA自身抗体的滴度（>1:10,000）远高于其他疾病中发现的滴度，可能导致家族性自主神经功能异常的病理变化。
