Hopkinson N D, Doherty M, Powell R J
Department of Immunology, Queen's Medical Centre, Nottingham.
Br J Rheumatol. 1993 Feb;32(2):110-5. doi: 10.1093/rheumatology/32.2.110.
The incidence and prevalence of systemic lupus erythematosus (SLE) in a well defined area in the Midlands was determined, by case ascertainment using multiple sources, during the period 1.5.89 to 30.4.90. This first such study of SLE in the UK showed incidence rates of 1.5/100,000/year for males and 6.5/100,000/year for females. The highest incidence was seen in age groups 40-49 and 50-59 years, with rates for females of 10.5 and 18.4/100,000/year respectively. Prevalence rates were 3.7/100,000/year for males and 45.4/100,000/year for females: SLE was found to be more prevalent amongst Afro-Caribbean groups. The socioeconomic status of the SLE patients was similar to the local study population, using social class by occupation and disadvantage by geographical area as indicators. Marked overlap between different sources of retrieval suggests that ascertainment of cases was high.
在1989年5月1日至1990年4月30日期间，通过多种来源的病例确诊，确定了英格兰中部一个明确界定区域内系统性红斑狼疮（SLE）的发病率和患病率。英国首次此类SLE研究显示，男性发病率为每年1.5/10万，女性为每年6.5/10万。最高发病率出现在40 - 49岁和50 - 59岁年龄组，女性发病率分别为每年10.5/10万和18.4/10万。男性患病率为每年3.7/10万，女性为每年45.4/10万：发现SLE在非洲加勒比人群中更为普遍。以职业划分的社会阶层和地理区域的不利因素为指标，SLE患者的社会经济状况与当地研究人群相似。不同检索来源之间存在明显重叠，表明病例确诊率很高。
