Keegan K, Rooke L, Hayman M, Spurr N K
Department of Microbiology, School of Medicine, State University of New York, Stony Brook 11794-8621.
Cytogenet Cell Genet. 1993;62(2-3):172-5. doi: 10.1159/000133465.
Fibroblast growth factor receptors (FGFRs) have recently been isolated and shown to be transmembrane tyrosine kinase receptors. The FGFR1 gene has previously been assigned to human chromosome 8 and the FGFR4 gene to human chromosome 5. Here we demonstrate, by using somatic cell hybrids, that the FGFR3 gene localizes to human chromosome 4, showing that it, too, resides on a chromosome distinct from those on which other FGFRs have been localized.
成纤维细胞生长因子受体(FGFRs)最近已被分离出来,并被证明是跨膜酪氨酸激酶受体。FGFR1基因先前已被定位到人类染色体8上,而FGFR4基因则被定位到人类染色体5上。在此,我们通过体细胞杂交实验证明,FGFR3基因定位于人类染色体4上,这表明它也位于一条与其他已定位FGFRs所在染色体不同的染色体上。