Jain N, Sudhakar C, Das M R
Centre for Cellular and Molecular Biology, Hyderabad, India.
FEBS Lett. 1993 Feb 8;317(1-2):147-51. doi: 10.1016/0014-5793(93)81511-w.
Tumor cell surface sialic acid levels determine a number of important properties governing cellular interactions and cell-cell communication. Towards understanding the mechanism of regulation of sialic acid levels upon cellular transformation, we have studied the regulation of expression of beta-galactoside alpha 2,6-sialyltransferase in a rat tumor, the Zajdela ascitic hepatoma. We demonstrate distinct differences in the regulation of expression of the enzyme in the tumor cells as compared to normal liver cells. The expression of sialyltransferase is regulated both at the transcriptional and post-transcriptional level in a tissue-specific manner.
肿瘤细胞表面唾液酸水平决定了许多控制细胞相互作用和细胞间通讯的重要特性。为了理解细胞转化过程中唾液酸水平的调节机制，我们研究了大鼠肿瘤——Zajdela腹水肝癌中β-半乳糖苷α2,6-唾液酸转移酶表达的调节。我们证明，与正常肝细胞相比，肿瘤细胞中该酶表达的调节存在明显差异。唾液酸转移酶的表达在转录和转录后水平均以组织特异性方式受到调节。
