Lack of effect of octreotide on parathyroid hormone levels and urinary excretion of epidermal growth factor.

To determine whether octreotide may acutely modify calcium homeostasis and/or inhibit the EGF production by the kidney, a subcutaneous injection of octreotide (100 micrograms) was administered to ten healthy volunteers. Blood and urine samples were collected at -30, 0, 60, 90, 120 and 180 minutes. Serum insulin, intact PTH, osteocalcin, total and ionized calcium and urinary EGF and creatinine were measured. There was no modification in serum PTH, osteocalcin and total or ionized calcium. There was no significant modification of urinary EGF, although a trend to decrease was evidenced.