Théon A P, Pascoe J R, Carlson G P, Krag D N
Department of Radiological Sciences, School of Veterinary Medicine, University of California, Davis 95616.
J Am Vet Med Assoc. 1993 Jan 15;202(2):261-7.
Twenty horses with 30 lesions were studied to evaluate the effects of intratumoral chemotherapy with cisplatin in sesame oil on equine sarcoids (n = 19), squamous cell carcinomas (n = 7), and squamous cell papillomas (n = 4). Treatment consisted of 4 sessions of intratumoral cisplatin chemotherapy at 2-week intervals. A controlled-release formulation of cisplatin in sesame oil was used to limit drug egress from the injection site. Mean dosage per session was 0.97 (+/- 0.17, SEM) mg of cisplatin/cm3 of tumor tissue treated for tumor volumes ranging from 10 to 20 cm3. Dosage tended to be slightly higher for smaller tumors and slightly lower for larger tumors. Tumor regression was observed in all horses. Complete response was observed in 18 of the sarcoids, 5 of the squamous cell carcinomas, and 4 of the squamous cell papillomas. The mean relapse-free interval was 21.6 and 14 months in horses with sarcoid and carcinoma/papilloma, respectively. The 1-year relapse-free rates were 87 and 65% for equine sarcoid and carcinoma/papilloma, respectively. In horses with relapse, 70% had tumor recurrence outside the treated field. Cisplatin-related local toxicosis was minimal. Intratumoral cisplatin chemotherapy was found to be a practical and effective treatment of sarcoid and squamous cell carcinoma/papilloma in horses.
对20匹马身上的30处病灶进行了研究，以评估瘤内注射顺铂的芝麻油制剂对马的肉瘤（n = 19）、鳞状细胞癌（n = 7）和鳞状细胞乳头瘤（n = 4）进行化疗的效果。治疗包括每隔2周进行4次瘤内顺铂化疗。使用顺铂的芝麻油控释制剂来限制药物从注射部位流出。对于体积在10至20立方厘米的肿瘤组织，每次治疗的平均剂量为0.97（±0.17，标准误）毫克顺铂/立方厘米肿瘤组织。较小的肿瘤剂量往往略高，较大的肿瘤剂量往往略低。所有马匹均观察到肿瘤消退。在19例肉瘤中有18例、7例鳞状细胞癌中有5例、4例鳞状细胞乳头瘤中有4例出现完全缓解。患有肉瘤和癌/乳头瘤的马匹的平均无复发间隔分别为21.6个月和14个月。马的肉瘤和癌/乳头瘤的1年无复发率分别为87%和65%。在复发的马匹中，70%的肿瘤在治疗区域外复发。顺铂相关的局部中毒反应极小。瘤内顺铂化疗被发现是治疗马的肉瘤和鳞状细胞癌/乳头瘤的一种实用且有效的方法。
