Schwartz S
Department of Medicine, School of Veterinary Medicine, Tufts University, North Grafton, MA 01536.
J Am Vet Med Assoc. 1993 Jan 15;202(2):278-80.
Naltrexone, an opioid antagonist recently advocated for the control of stereotypic behavioral patterns in horses and dogs, induced an intense dose-related pruritic reaction in a dog with tail-chasing and self-mutilating behavior. Used in human beings primarily as an adjunct in the treatment of opioid abusers, naltrexone's adverse effects include dermatologic signs, such as alopecia and pruritus, observed in < 1% of human patients. In contrast to previously reported findings, naltrexone treatment was of limited benefit to the dog of this report. During administration of the drug, stereotypic patterns were reduced but did not disappear. Although naltrexone may be effective in controlling certain obsessive-compulsive disorders, its inconsistent therapeutic value, prohibitive cost to pet owners, and side effects such as the pruritus observed in the dog of this report may restrict use of this drug.
纳曲酮是一种阿片类拮抗剂，最近有人主张用它来控制马和狗的刻板行为模式。在一只出现追尾和自残行为的狗身上，纳曲酮引发了强烈的剂量相关瘙痒反应。纳曲酮主要用于人类作为治疗阿片类药物滥用者的辅助药物，其不良反应包括皮肤症状，如脱发和瘙痒，在不到1%的人类患者中观察到。与之前报道的结果相反，纳曲酮治疗对本报告中的狗益处有限。在给药过程中，刻板行为模式有所减少但并未消失。尽管纳曲酮可能对控制某些强迫症有效，但其治疗价值不一致、宠物主人成本过高以及本报告中狗身上观察到的瘙痒等副作用可能会限制该药物的使用。
