Overall K L
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010.
J Am Vet Med Assoc. 1994 Dec 15;205(12):1733-41.
Atypical, stereotypic motor and locomotor behavior was observed in 3 dogs. In 1 dog, the behavior included circling, vocalization, and snapping; in another, circling associated with pica and aerophagia; and in a third, gradually intensifying locomotor behavior stimulated by bright light. This behavior interfered with normal interaction between their owners and the dogs, and has been associated with obsessive-compulsive disorders. Treatment with clomipramine, along with other psychotropic medications and behavioral modification, suppressed the inappropriate behavior in all dogs; in 2 of the 3 dogs, the condition worsened when clomipramine treatment was withdrawn. Clomipramine may be helpful in treatment of such behavioral disorders, but one should consider the ability of such drugs to mask or worsen metabolic or neurologic problems, to induce toxicoses when used at inappropriate dosages, and to be abused by human beings.
在3只狗身上观察到了非典型的、刻板的运动和移动行为。在1只狗身上，行为包括转圈、吠叫和咬噬；在另一只狗身上，转圈行为与异食癖和气食症有关；在第三只狗身上，强光刺激导致其运动行为逐渐加剧。这种行为干扰了它们的主人与狗之间的正常互动，并且与强迫症有关。氯米帕明联合其他精神药物及行为矫正治疗，抑制了所有狗的不当行为；在3只狗中的2只中，停用氯米帕明治疗后病情恶化。氯米帕明可能有助于治疗此类行为障碍，但人们应考虑此类药物掩盖或加重代谢或神经问题、不当剂量使用时诱发中毒以及被人滥用的可能性。
