Ambrosini P J, Bianchi M D, Rabinovich H, Elia J
Division of Child and Adolescent Psychiatry, Medical College of Pennsylvania/Eastern Pennsylvania Psychiatric Institute, Philadelphia 19129.
J Am Acad Child Adolesc Psychiatry. 1993 Jan;32(1):1-6. doi: 10.1097/00004583-199301000-00001.
Part I of this review critically evaluates antidepressants' benefits for children and adolescents with affective disorders. The effectiveness of antidepressants is characterized with specific references regarding diagnostic methodology, measurement characteristics, response definitions, recovery rates, length of treatment, and plasma level monitoring. Antidepressants' efficacy for depressed youths is quite circumscribed, and their superiority to placebo remains unproved. Their intriguing lack of efficacy in affective disorders is discussed based on methodological issues and from a theoretical perspective. Clinical and research implications are presented.
本综述的第一部分批判性地评估了抗抑郁药对患有情感障碍的儿童和青少年的益处。抗抑郁药的有效性通过有关诊断方法、测量特征、反应定义、恢复率、治疗时长和血浆水平监测的具体参考文献进行了描述。抗抑郁药对抑郁青少年的疗效相当有限，其优于安慰剂的效果仍未得到证实。基于方法学问题并从理论角度讨论了它们在情感障碍中令人感兴趣的疗效缺失情况。还阐述了临床和研究方面的意义。
