阿扑吗啡治疗帕金森病：皮下注射与舌下含服途径的比较。
Apomorphine in treatment of Parkinson's disease: comparison between subcutaneous and sublingual routes.
作者信息
Deffond D, Durif F, Tournilhac M
机构信息
Clinique Neurologique, Hôpital Fontmaure, Chamalieres, France.
出版信息
J Neurol Neurosurg Psychiatry. 1993 Jan;56(1):101-3. doi: 10.1136/jnnp.56.1.101.
Abstract
The efficacy of two routes of apomorphine, subcutaneous (SC) and sublingual (SL), successively administered in 7 Parkinsonian patients with motor fluctuations, was compared in reducing the daily duration of "off" phases. The mean duration of SC and SL treatment was 7.7 and 6.8 months respectively. The mean time spent in "off" phase was 55% after SC and 68% after SL treatment. The mean time before turning "on" after an "off" period was 14 minutes after SC and 28 minutes after SL treatment. Two patients developed stomatitis after SL route. SL apomorphine may be helpful in the treatment of motor fluctuations in PD.
摘要
比较了皮下（SC）和舌下（SL）两种阿扑吗啡给药途径先后用于7例有运动波动的帕金森病患者时，减少每日“关”期持续时间的疗效。SC和SL治疗的平均持续时间分别为7.7个月和6.8个月。SC治疗后“关”期的平均时间为55%，SL治疗后为68%。“关”期后“开”动前的平均时间，SC治疗后为14分钟，SL治疗后为28分钟。2例患者经SL途径给药后出现口腔炎。舌下阿扑吗啡可能有助于治疗帕金森病的运动波动。
相似文献
1
Apomorphine in treatment of Parkinson's disease: comparison between subcutaneous and sublingual routes.阿扑吗啡治疗帕金森病：皮下注射与舌下含服途径的比较。
J Neurol Neurosurg Psychiatry. 1993 Jan;56(1):101-3. doi: 10.1136/jnnp.56.1.101.
2
Sublingual apomorphine in Parkinson's disease: a clinical and pharmacokinetic study.帕金森病中舌下含服阿扑吗啡：一项临床与药代动力学研究。
Clin Neuropharmacol. 1991 Oct;14(5):432-7. doi: 10.1097/00002826-199110000-00007.
3
Model-based comparison of subcutaneous versus sublingual apomorphine administration in the treatment of motor fluctuations in Parkinson's disease.基于模型的皮下与舌下注射阿扑吗啡治疗帕金森病运动波动的比较
J Pharmacokinet Pharmacodyn. 2024 Aug;51(4):385-393. doi: 10.1007/s10928-024-09914-x. Epub 2024 Apr 5.
4
Apomorphine for motor fluctuations and freezing in Parkinson's disease.阿扑吗啡用于帕金森病的运动波动和冻结现象
Ann Pharmacother. 1995 Mar;29(3):282-8. doi: 10.1177/106002809502900310.
5
[Sublingual administration of apomorphine in the treatment of motor fluctuations in Parkinson disease].[阿扑吗啡舌下含服治疗帕金森病运动波动]
Rev Neurol (Paris). 1992;148(10):610-4.
6
Long-term safety, tolerability and efficacy of apomorphine sublingual film in patients with Parkinson's disease complicated by OFF episodes: a phase 3, open-label study.阿扑吗啡舌下膜治疗伴有关期发作的帕金森病患者的长期安全性、耐受性和疗效：一项 3 期、开放性研究。
J Neurol. 2024 Jun;271(6):3554-3570. doi: 10.1007/s00415-024-12323-2. Epub 2024 Mar 28.
7
Efficacy of sublingual apomorphine in Parkinson's disease.舌下含服阿扑吗啡治疗帕金森病的疗效
J Neurol Neurosurg Psychiatry. 1990 Dec;53(12):1105. doi: 10.1136/jnnp.53.12.1105.
8
Apomorphine Sublingual Film Compared with Subcutaneous Apomorphine for OFF Episodes in Parkinson's Disease: An Open-Label, Randomized, Crossover Study.阿扑吗啡舌下薄膜与皮下注射阿扑吗啡治疗帕金森病“关”期发作的比较：一项开放标签、随机、交叉研究。
J Parkinsons Dis. 2023;13(8):1329-1342. doi: 10.3233/JPD-230072.
9
Absorption of apomorphine by various routes in parkinsonism.帕金森病中阿扑吗啡经不同途径的吸收情况。
Mov Disord. 1991;6(3):212-6. doi: 10.1002/mds.870060304.
10
[Subcutaneous administration of apomorphine in motor fluctuations in Parkinson's disease].[皮下注射阿扑吗啡治疗帕金森病运动波动]
Rev Neurol (Paris). 1990;146(2):116-22.
引用本文的文献
1
Intermittent Apomorphine Use for off Period Rescue in Parkinson's Disease: A Pragmatic Review of over Three Decades of Clinical Experience.间歇性使用阿扑吗啡用于帕金森病“关”期急救：对三十多年临床经验的实用综述
Mov Disord Clin Pract. 2022 Oct 27;10(2):190-208. doi: 10.1002/mdc3.13593. eCollection 2023 Feb.
2
A deep eutectic-based, self-emulsifying subcutaneous depot system for apomorphine therapy in Parkinson's disease.基于深共晶溶剂的阿扑吗啡皮下储库系统用于帕金森病的治疗。
Proc Natl Acad Sci U S A. 2022 Mar 1;119(9). doi: 10.1073/pnas.2110450119.
3
Challenges and trends in apomorphine drug delivery systems for the treatment of Parkinson's disease.用于治疗帕金森病的阿扑吗啡给药系统的挑战与趋势
Asian J Pharm Sci. 2018 Nov;13(6):507-517. doi: 10.1016/j.ajps.2017.11.004. Epub 2017 Dec 6.
4
Old Drugs, New Delivery Systems in Parkinson's Disease.帕金森病的老药新剂型
Drugs Aging. 2019 Sep;36(9):807-821. doi: 10.1007/s40266-019-00682-9.
5
Apomorphine and the dopamine hypothesis of schizophrenia: a dilemma?阿扑吗啡与精神分裂症的多巴胺假说：一个困境？
J Psychiatry Neurosci. 2001 May;26(3):203-20.
6
Subcutaneous apomorphine in late stage Parkinson's disease: a long term follow up.皮下注射阿扑吗啡治疗晚期帕金森病：长期随访
J Neurol Neurosurg Psychiatry. 1998 Nov;65(5):709-16. doi: 10.1136/jnnp.65.5.709.
7
Regulation of aromatic L-amino acid decarboxylase in rat striatal synaptosomes: effects of dopamine receptor agonists and antagonists.大鼠纹状体突触体中芳香族L-氨基酸脱羧酶的调节：多巴胺受体激动剂和拮抗剂的作用。
Br J Pharmacol. 1994 May;112(1):23-30. doi: 10.1111/j.1476-5381.1994.tb13023.x.
本文引用的文献
1
Subcutaneous apomorphine in Parkinson's disease.帕金森病中的皮下注射阿扑吗啡
Lancet. 1988 Apr 23;1(8591):943. doi: 10.1016/s0140-6736(88)91755-2.
2
Subcutaneous apomorphine in parkinsonian on-off oscillations.皮下注射阿扑吗啡治疗帕金森病的开关现象
Lancet. 1988 Feb 20;1(8582):403-6. doi: 10.1016/s0140-6736(88)91193-2.
3
Sublingual apomorphine and Parkinson's disease.舌下含服阿扑吗啡与帕金森病
J Neurol Neurosurg Psychiatry. 1989 Dec;52(12):1440. doi: 10.1136/jnnp.52.12.1440.
4
[Subcutaneous administration of apomorphine in motor fluctuations in Parkinson's disease].[皮下注射阿扑吗啡治疗帕金森病运动波动]
Rev Neurol (Paris). 1990;146(2):116-22.
5
Subcutaneous apomorphine in the treatment of Parkinson's disease.皮下注射阿扑吗啡治疗帕金森病。
J Neurol Neurosurg Psychiatry. 1990 Feb;53(2):96-101. doi: 10.1136/jnnp.53.2.96.
6
Intranasal apomorphine in Parkinson's disease.帕金森病中的鼻内阿扑吗啡
Neurology. 1991 May;41(5):761-2. doi: 10.1212/wnl.41.5.761-a.
7
Sublingual apomorphine in the treatment of Parkinson's disease complicated by motor fluctuations.舌下含服阿扑吗啡治疗帕金森病合并运动波动
Clin Neuropharmacol. 1991 Dec;14(6):556-61. doi: 10.1097/00002826-199112000-00008.
8
Sublingual apomorphine in Parkinson's disease: a clinical and pharmacokinetic study.帕金森病中舌下含服阿扑吗啡：一项临床与药代动力学研究。
Clin Neuropharmacol. 1991 Oct;14(5):432-7. doi: 10.1097/00002826-199110000-00007.
Zotero 插件