Sasaki M, Ichiya Y, Kuwabara Y, Otsuka M, Fukumura T, Kawai Y, Koga H, Masuda K
Department of Radiology, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
J Nucl Med. 1993 Feb;34(2):288-90.
We have encountered two cases of bone tumors with high 18F-fluorodeoxyglucose (FDG) uptake and negative 99mTc-HMDP bone scintigraphy, including a patient with myeloma and a patient with a metastatic bone tumor from esophageal cancer. Bone scintigraphy with a 99mTc-phosphate complex reflects osteoblastic activity in the bone tissue surrounding the tumor, whereas the accumulation of FDG is associated with the metabolic activity of the tumor itself. An FDG-PET study can therefore be used as a complementary study for the detection and follow-up of bone tumors when a 99mTc-phosphate bone scintigram is negative.
我们遇到了两例18F-氟脱氧葡萄糖（FDG）摄取高而99m锝-亚甲基二膦酸盐（HMDP）骨闪烁显像阴性的骨肿瘤病例，其中一例为骨髓瘤患者，另一例为食管癌骨转移瘤患者。99m锝-磷酸盐复合物骨闪烁显像反映肿瘤周围骨组织的成骨活性，而FDG的聚集与肿瘤本身的代谢活性相关。因此，当99m锝-磷酸盐骨闪烁显像为阴性时，FDG-PET研究可作为骨肿瘤检测和随访的补充研究。
