Siber G R, Werner B G, Halsey N A, Reid R, Almeido-Hill J, Garrett S C, Thompson C, Santosham M
Laboratory of Infectious Diseases, Dana-Farber Cancer Institute, Boston, Massachusetts 02115.
J Pediatr. 1993 Feb;122(2):204-11. doi: 10.1016/s0022-3476(06)80114-9.
Passively acquired antibody may interfere with the active antibody response to live viral vaccines such as measles and rubella. To evaluate the duration of this inhibitory effect, we measured the measles and rubella antibody responses of Apache children immunized with measles, mumps, and rubella vaccine at varying intervals after administration of an immune globulin termed bacterial polysaccharide immune globulin (BPIG). This specific immune globulin contained measles and rubella antibody titers similar to those in standard intramuscularly and intravenously administered immune globulins. Antibody responses to measles vaccine were inhibited for up to 5 months after a BPIG dose of 80 mg IgG per kilogram of body weight, but responses to rubella vaccine were inhibited for only 2 months. Most children who had a decreased measles antibody response to primary measles, mumps, and rubella immunization given 1 1/2 to 4 months after BPIG administration responded to a booster immunization given 6 months after their last BPIG dose. We conclude that high doses of immune globulin (> 10 mg/kg) may inhibit the antibody response to measles for more than 3 months. We propose that the interval between administration of immune globulin and measles and rubella immunization be adjusted on the basis of the dose of immune globulin.
被动获得的抗体可能会干扰对麻疹和风疹等活病毒疫苗的主动抗体反应。为了评估这种抑制作用的持续时间，我们在给予一种名为细菌多糖免疫球蛋白（BPIG）的免疫球蛋白后，在不同间隔时间测量了接种麻疹、腮腺炎和风疹疫苗的阿帕奇儿童的麻疹和风疹抗体反应。这种特定的免疫球蛋白所含的麻疹和风疹抗体滴度与标准肌肉注射和静脉注射免疫球蛋白中的抗体滴度相似。在每公斤体重给予80毫克IgG的BPIG剂量后，对麻疹疫苗的抗体反应被抑制长达5个月，但对风疹疫苗的反应仅被抑制2个月。大多数在BPIG给药后1个半月至4个月接受初次麻疹、腮腺炎和风疹免疫接种时麻疹抗体反应降低的儿童，在最后一次BPIG剂量后6个月接受加强免疫接种时有反应。我们得出结论，高剂量的免疫球蛋白（>10毫克/千克）可能会在3个多月的时间内抑制对麻疹的抗体反应。我们建议根据免疫球蛋白的剂量调整免疫球蛋白与麻疹和风疹免疫接种之间的间隔时间。
