Eidelberg D, Johnson G, Barnes D, Tofts P S, Delpy D, Plummer D, McDonald W I
NMR Research Group, Institute of Neurology, National Hospital for Nervous Diseases, Queen Square, London.
Magn Reson Med. 1988 Mar;6(3):344-52. doi: 10.1002/mrm.1910060312.
Perfluorocarbon (PFC) emulsions have been developed as oxygen carrying blood substitutes. High fluorine concentrations allow them to be used in 19F NMR imaging of blood vessels. Furthermore, 19F relaxation times in PFCs are dependent on oxygen tension (pO2) so that NMR imaging may provide a noninvasive method of measuring spatially localized pO2 values in vivo. Using these principles, we have formed 19F images and calculated pO2 maps of the cat brain.
全氟碳（PFC）乳剂已被开发用作携氧血液替代品。高氟浓度使其可用于血管的19F核磁共振成像。此外，全氟碳中的19F弛豫时间取决于氧分压（pO2），因此核磁共振成像可能提供一种在体内测量空间局部pO2值的非侵入性方法。利用这些原理，我们已形成猫脑的19F图像并计算出pO2图谱。
