Berrazueta J R, Salas E, Ochoteco A, Poveda J J, Sánchez de Vega M J
Cátedra y Servicio de Cardiología, Hospital Universitario Marqués de Valdecilla, Santander.
Rev Esp Cardiol. 1993 Jan;46(1):10-4.
Nitric oxide is a biological mediator. In nervous system it acts like neurotransmitter and also modulate acute inflammation. In the peripheral nervous system it blocks the nociceptive stimulus through an increase in postsynaptic neurone GMPc level. Nitro-vasodilator drugs like nitroglycerin are metabolised in the cell given rise to short lived intermediates, which liberating nitric oxide that activate the guanylate cyclase enzyme, increasing the GMPc in smooth muscle cell. This study show that nitroglycerin produces an analgesic action. The pain sensitivity to pinprick test in forearm with nitroglycerin has shown a decrease in a significative manner against placebo. We speculate that nitroglycerin could have a similar action as endogenous nitric oxide in nervous system.
一氧化氮是一种生物介质。在神经系统中，它起着神经递质的作用，还能调节急性炎症。在周围神经系统中，它通过提高突触后神经元鸟苷酸环化酶（GMPc）水平来阻断伤害性刺激。像硝酸甘油这样的硝基血管扩张药物在细胞内代谢，产生寿命短暂的中间体，这些中间体释放出一氧化氮，激活鸟苷酸环化酶，增加平滑肌细胞中的GMPc。这项研究表明硝酸甘油具有镇痛作用。使用硝酸甘油后，前臂针刺试验的疼痛敏感性与安慰剂相比有显著降低。我们推测硝酸甘油在神经系统中可能具有与内源性一氧化氮类似的作用。
