Karlin S, Brendel V
Department of Mathematics, Stanford University, CA 94305.
Science. 1993 Jan 29;259(5095):677-80. doi: 10.1126/science.8430316.
The highly nonrandom character of genomic DNA can confound attempts at modeling DNA sequence variation by standard stochastic processes (including random walk or fractal models). In particular, the mosaic character of DNA consisting of patches of different composition can fully account for apparent long-range correlations in DNA.
基因组DNA的高度非随机特性可能会使通过标准随机过程(包括随机游走或分形模型)对DNA序列变异进行建模的尝试变得复杂。特别是,由不同组成部分的片段构成的DNA的镶嵌特性可以充分解释DNA中明显的长程相关性。