Oian P, Aune B
Kvinneklinikken, Regionsykehuset i Tromsø.
Tidsskr Nor Laegeforen. 1993 Jan 20;113(2):193-6.
We review the evidence that hormone replacement therapy protects against the development of cardiovascular disease in women. Most studies show that this treatment reduces risk of cardiovascular disease by about 50%. The results are reasonably consistent, and biologically plausible. The protective effects are mediated through effects on lipid metabolism, but also through direct effects on vessel wall physiology and blood flow. The beneficial effect of hormone replacement therapy seems to be most marked in high-risk patients and in women with severe coronary artery disease.
我们回顾了激素替代疗法可预防女性心血管疾病发生的相关证据。大多数研究表明，这种治疗可将心血管疾病风险降低约50%。结果相当一致，且从生物学角度来看是合理的。其保护作用是通过对脂质代谢的影响介导的，但也通过对血管壁生理和血流的直接作用来实现。激素替代疗法的有益效果在高危患者和患有严重冠状动脉疾病的女性中似乎最为显著。
