Bibikova M V, Ivanitskaia L P, Makukho L V
Antibiotiki. 1977 Jan;22(1):74-7.
The cytostatic effect of endoxan, Tiotef, bleomycin and other drugs was increased by addition of a thioloprovic compound of N-ethylenmaleimide (N-EM) to the cultures of cancer cells in doses not affecting the synthesis of nucleic acids in these cultures. The sensibilizing effect of N-EM against the antitumor drugs was due to blocking of SH-enzymes responsible of synthesis or reparation of DNA. Thus, a simultaneous effect of N-EM on the thiol cycle and synthesis of nucleic acids was synergistic for a number of antitumor drugs. It provided an increased effect of the cytostatics in doses having no activity under conditions of routine in vitro tests.
在癌细胞培养物中添加N - 乙基马来酰亚胺（N - EM）这种硫醇类化合物，在不影响这些培养物中核酸合成的剂量下，可增强癌得星、替奥拓芬、博来霉素及其他药物的细胞生长抑制作用。N - EM对抗肿瘤药物的增敏作用是由于其阻断了负责DNA合成或修复的巯基酶。因此，N - EM对硫醇循环和核酸合成的同时作用，对多种抗肿瘤药物具有协同作用。在常规体外试验条件下无活性的剂量下，它提高了细胞生长抑制剂的作用效果。
