Volkolupova O P, Makukho L V
Antibiotiki. 1982 Oct;27(10):779-81.
The cytostatic effect of some semi-synthetic derivative of rubomycin, an antitumor antibiotic, was studied with two methods, i.e. the method of spectrophotometric determination of the increase of the total amount of nucleic acids and the radiometric method based on measuring the intensity of incorporation of labeled thymidine. The results obtained with the two methods were similar. 9 semi-synthetic derivatives of rubomycin were studied with respect to the tumor cells NK/Li. The cytostatic effect of 8 out of these derivatives was 2-170 times lowers than that of rubomycin. The cytostatic effect of N-ethylrubomycin was equal to that of the initial antibiotic.
用两种方法研究了抗肿瘤抗生素柔红霉素的一些半合成衍生物的细胞生长抑制作用，即分光光度法测定核酸总量增加的方法和基于测量标记胸苷掺入强度的放射性方法。用这两种方法获得的结果相似。针对肿瘤细胞NK/Li研究了9种柔红霉素的半合成衍生物。其中8种衍生物的细胞生长抑制作用比柔红霉素低2至170倍。N-乙基柔红霉素的细胞生长抑制作用与初始抗生素相同。
