Gum G G, Gelatt K N, Gelatt J K, Jones R
Gwathmey-Adams Laboratory for Visual Science, College of Veterinary Medicine, University of Florida, Gainesville 32610-0126.
Am J Vet Res. 1993 Feb;54(2):287-93.
Topically applied demecarium bromide (0.125 and 0.25%) and echothiophate iodide (0.125 and 0.25%) solutions were evaluated in Beagles with normotensive eyes and Beagles with inherited glaucoma. In single-dose studies, the effects of intraocular pressure (IOP) and pupil size (PS) were measured in eyes before drug treatment and in drug- and nondrug-treated eyes. Both concentrations of the 2 drugs induced long-term miosis and decrease in IOP in normotensive eyes of Beagles and of eyes of Beagles with inherited glaucoma. Demecarium bromide (0.125 and 0.5%) decreased IOP for 49 and 55 hours, respectively. Echothiophate iodide (0.125 and 0.5%) reduced IOP for 25 and 53 hours, respectively. The miosis associated with both concentrations of the 2 drugs generally paralleled the decreases in IOP.
在血压正常的比格犬和患有遗传性青光眼的比格犬中，评估了局部应用的溴化地美卡林（0.125%和0.25%）和碘依可酯（0.125%和0.25%）溶液。在单剂量研究中，在药物治疗前以及药物治疗和未治疗的眼睛中测量眼压（IOP）和瞳孔大小（PS）。两种药物的两种浓度均在血压正常的比格犬眼睛和患有遗传性青光眼的比格犬眼睛中引起长期瞳孔缩小和眼压降低。溴化地美卡林（0.125%和0.5%）分别使眼压降低49小时和55小时。碘依可酯（0.125%和0.5%）分别使眼压降低25小时和53小时。与两种药物的两种浓度相关的瞳孔缩小通常与眼压降低情况平行。
