King T C, Gum G G, Gelatt K N
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610-0126.
Am J Vet Res. 1991 Dec;52(12):2067-70.
A new topically administered anhydrase inhibitor, MK-927, was evaluated for its ocular hypotensive activity in normotensive and glaucomatous Beagles. Single- and multiple-dose studies were performed. Six concentrations of the drug were evaluated in the single-dose study and the 2% solution was used for multiple-dose evaluation. The decrease in intraocular pressure (IOP) was greater in glaucomatous Beagles at the higher concentrations of the drug. The 2 and 4% solutions of MK-927 significantly lowered IOP (mean, 5 mm of Hg; SEM +/- 1.6 and SEM +/- 1.2, respectively) in normotensive and glaucomatous Beagles. In the multiple-dose study, IOP was significantly decreased in the normotensive (mean, 4 mm of Hg; SEM +/- 0.74) and glaucomatous Beagles (mean, 9 mm of Hg; SEM +/- 1.2). The maximal effect was observed by day 4. A contralateral effect was found in glaucomatous Beagles, with the maximal effect on day 4.
一种新的局部给药的碳酸酐酶抑制剂MK-927，在正常血压和青光眼的比格犬中进行了眼内降压活性评估。进行了单剂量和多剂量研究。在单剂量研究中评估了六种药物浓度，并使用2%溶液进行多剂量评估。在较高药物浓度下，青光眼比格犬的眼压（IOP）下降幅度更大。MK-927的2%和4%溶液在正常血压和青光眼比格犬中均显著降低眼压（平均值分别为5 mmHg；标准误±1.6和标准误±1.2）。在多剂量研究中，正常血压比格犬（平均值为4 mmHg；标准误±0.74）和青光眼比格犬（平均值为9 mmHg；标准误±1.2）的眼压均显著降低。在第4天观察到最大效果。在青光眼比格犬中发现了对侧效应，最大效果出现在第4天。
