Morris A B, Brown R B, Sands M
Department of Medicine, Baystate Medical Center, Springfield, Massachusetts 01199.
Antimicrob Agents Chemother. 1993 Jan;37(1):1-7. doi: 10.1128/AAC.37.1.1.
Rifampin has very broad antimicrobial properties with in vitro activities against many bacteria, mycobacteria, higher bacteria, chlamydia, fungi, parasites, and viruses (Table 1). The clinical use of rifampin is more limited, in part because of the lack of in vivo human clinical studies demonstrating its efficacy. Investigators have valid concerns regarding the emergence of resistance of mycobacteria if widespread use of rifampin becomes common, although this has not been well documented. Because rifampin obtains therapeutic levels intracellularly and is distributed widely throughout the body, the antibiotic potentially could be used on a broader scale, but more studies will be needed to demonstrate its clinical utility.
利福平具有非常广泛的抗菌特性，在体外对许多细菌、分枝杆菌、高等细菌、衣原体、真菌、寄生虫和病毒均有活性（表1）。利福平的临床应用较为有限，部分原因是缺乏人体临床研究来证明其疗效。尽管尚未有充分的文献记载，但研究人员对分枝杆菌耐药性的出现存在合理担忧，如果利福平广泛使用，这种情况可能会普遍发生。由于利福平在细胞内可达到治疗浓度且在全身广泛分布，这种抗生素可能有更广泛的应用前景，但还需要更多研究来证明其临床效用。
