Haagensen D E, Mazoujian G, Holder W D, Kister S J, Wells S A
Ann Surg. 1977 Mar;185(3):279-85. doi: 10.1097/00000658-197703000-00005.
A radioimmunoassay has been developed for one of the major proteins isolated from human breast cyst fluid. Immunologically this protein is identical to a protein present in both human milk and saliva. Ninety-two normal women had plasma levels of this protein below 100 ng/ml (range 7-81 ng/ml; mean 31 ng/ml), and 85% had plasma levels below 50 ng/ml. More than one-half of the women with active gross cystic disease of the breast had plasma levels above 50 ng/ml. None of these women, however, had plasma levels above 150 ng/ml. A significant percentage of women with advanced breast carcinoma have been found to have plasma concentrations of this protein greater than 150 ng/ml.
已开发出一种针对从人乳腺囊肿液中分离出的一种主要蛋白质的放射免疫测定法。从免疫学角度来看，这种蛋白质与人乳和唾液中存在的一种蛋白质相同。92名正常女性的这种蛋白质血浆水平低于100纳克/毫升（范围为7 - 81纳克/毫升；平均为31纳克/毫升），85%的人血浆水平低于50纳克/毫升。患有明显乳腺囊肿性疾病的女性中，超过一半的人血浆水平高于50纳克/毫升。然而，这些女性中没有人血浆水平高于150纳克/毫升。已发现相当比例的晚期乳腺癌女性这种蛋白质的血浆浓度大于150纳克/毫升。
